Objective:To compare product appearance and internal quality of Fritillariae Thunbergii Bulbus under four different origin processing technologies without vulcanization

in order to provide experimental evidence for selecting a origin processing technology which is advanced and suitable for promotion. Method: Taking product appearance

moisture content

peimine and peiminine content as indicators

effects of four different origin processing technologies on product appearance and internal quality of Fritillariae Thunbergii Bulbus were compared

including shell powder drying

sliced drying

freeze drying and microwave drying.HPLC-ELSD was adopted to determine contents of peimine and peiminine with mobile phase of acetonitrile-water-diethylamine(70: 30: 0.03)

flow rate of 0.8 mL · min-1

drift tube temperature of 85 ℃ and carrier gas flow rate of 2.2 L ·min-1. Result: Product appearance was quite different under various process conditions

freeze drying product was the best;moisture content conformed standards in the 2010 edition of〈Chinese Pharmacopoeia〉.Linear ranges of peimine and peiminine were 0.925-4.625 μg and 0.94-4.7 μg;average recovery of total content of peimine and peiminine was 98.58% with RSD of 1.3%.Total content of peimine and peiminine had some differences under various process conditions

freeze drying product was the highest

microwave drying and sliced drying followed

shell powder drying product was the lowest. Conclusion: Quality of Fritillariae Thunbergii Bulbus should focus on security of origin processing technology

microwave drying process can be instead of traditional origin processing technologies.