Objective:To study the effect of Ailuo Kechuanning on therapeutic effect of rats with chronic obstructive pulmonarydisease(COPD). Method: Lipopolysaccharide(LPS) smoke was used to COPD rat model; the experimental animals were randomly divided into normal control group

model group

Ailuo Kechuanning group(7.75

15.52

31.04 g · kg-1 · d-1).The normal control group

model group were given intragastrically the normal saline solution

while other groups were given corresponding herbal drugs intragastrically(7.75

15.52

31.04 g · kg-1 · d-1) for 14 days.Study of effects lung function

blood gas indexes and pathology change of Ailuo Kechuanning in the rats of all groups before and after treatment. Result: The levels of forced vital capacity(FVC)

forced expiratory volume in 1second(FEV1)

FEV1/FVC

forced expiratory flow (FEF)25-75

maximum midexpiratory flow(MMF)

peak expiratory flow(PEF) and potential of hydrogen(pH)

arterial oxygen pressure(PaO2)

arterial oxygen saturation(SaO2) were markedly lower

while partial pressure of carbon dioxide in artery (PaCO2)keep higher in the model group compared with those in the normal control group(P<0.05

P<0.01).The levels of FVC

FEV1

FEV1/FVC

FEF25-75

MEFV

PEF and pH

PaO2

SaO2 were markedly higher

but PaCO2 were lower in the Ailuo Kechuanning group (15.52 g · kg-1 · d-1 than those in model group

lung tissue inflammation significantly reduce. Conclusion: Theeffects of Ailuo Kechuanning for treatment of COPD may improve the pulmonary function and protect the lung tissue.