Objective:To investigate the effect of Jinkui Shenqi Wan(JKSQ) on insulin receptor (InsR) gene expression in skeletal muscle. Method: With 4 weeks fed high fat high sugar diet

male SD SPF rats of 6 weeks were induced diabete by intraperitoneal injection with streptozotocin. After 4 days the model rats were randomly divided into model group

metformin group

JKSQ low dose group and high dose group. The normal group and model group were given physiological saline

metformin group was given metformin (100 mg · kg-1)

JKSQ low dose group and high dose group were given JKSQ (10

20 g · kg-1) by gavage for 4 weeks. Hexokinase (HK)

6-phosphofructokinase-1(PFK) activity of skeletal muscle were detected. The mRNA and protein expression lever of InsR were detected with RT-PCR and Western blot. Result: As compared with normal group

HK and PFK activity decreased in model group (P<0.01)

the mRNA and protein expression of InsR were decreased markedly (P<0.01). During 4 weeks with drug treatment

as compared with the model group

medicine HK and PFK activity were significantly increased in positive control group

JKSQ low dose group and high dose group (P<0.05);while each of the above groups InsR expression on mRNA and protein were significantly increased (P<0.05). Conclusion: JKSQ can increase the mRNA and protein lever expression of InsR

and increas HK and PFK activity

to promote the oxidation of glucose utilization in skeletal muscle.