CHANG Xiu-juan, ZHANG Shuai, CHEN Jian, et al. Effect of Reduning Injection on Acute Lung Injury of Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(22): 172-175.
DOI:
CHANG Xiu-juan, ZHANG Shuai, CHEN Jian, et al. Effect of Reduning Injection on Acute Lung Injury of Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(22): 172-175. DOI: 10.13422/j.cnki.syfjx.2014220172.
Effect of Reduning Injection on Acute Lung Injury of Rats
Objective:To investigate the mechanism and the rapeutic effect of Reduning injection(RDN) on acute lung injury(ALI) in rats. Method: Sixty rats were randomly divided into six groups
normal group
model group
positive control group (dexamethasone
2 mg · kg-1)
high-
medium-
low-dose RDN groups (10.16
5.08
2.54 g · kg-1).The ALI rats was induced by ipopolysaccharide(LPS) except for rats in normal group. The effects of wet /dry weighto (W/D) ratio in lung
the total protein contents of bronchoalveolar lavage fluid (BALF)
superoxide dismutase (SOD)
malondialdehyde (MDA)
myeloperoxidase (MPO) in serum and interleukin(IL) -1β
tumor necrosis factor (TNF) -α
IL-10 in lung homogenate were observed. Result: The W/D ratio
BALF
the content of MDA
IL-1β
TNF-α
IL-10 were decreased
the activity of MPO was inhibited and the activity of SOD was activated in model group. The above indexes were all improved in all dosage of RDN groups(P<0.01
P<0.05). Conclusion: RDN can improve the pathological changes of lung tissueand reduce the oxidative stress reaction of ALI process. Its mechanism may be achieved by reducing the inflammatory factor in vivo.
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