Objective:To investigate the clinical effects of Baizi Yangxin decoction combined with Shugan Ningshen powder in the treatment of generalized anxiety disorder. Method: One hundred and twenty patients with generalized anxiety disorder were chosen and randomly divided into the control group (60 patients) and trational Chiese medicine (TCM) prescription group (60 patients). Patients in control group received escitalopram oxalate and patients in TCM prescription group received Baizi Yangxin decoction and Shugan Ningshen powder. The clinical efficacy

self-rating anxiety scale(SAS) score

hamilton anxiety scale(HAMA) score

simple health survey scale(SF-36) score and recurrence rate between two groups were compared before and after treatment. Result: The clinical efficacy of TCM prescription group were better than control group with statistically significant differences (P<0.05). The SAS score

HAMA score and SF-36 score after treatment of both groups were better than before with statistically significant differences (P<0.05). Besides

the effect of TCM prescription group were better than control group

with statistically significant differences (P<0.05). The recurrence rate of TCM prescription group were lower than control group with statistically significant (P<0.05). Conclusion: Compared with western medicine

using Baizi Yangxin decoction combined with Shugan Ningshen powder could efficiently improve the anxiety symptoms and the quality of life

and reduce the risk of recurrence in the treatment of generalized anxiety disorder.