Objective:To study the effect of auxiliary treatment of Banxia Xiexin decoction combined with domperidone in treating functional dyspepsia. Method: Eighty patients with functional dyspepsia were enrolled and divided into observation group and control group. Patients in observation group received auxiliary treatment of Banxia Xiexin decoction combined with domperidone. Patients in control group received domperidone alone. Then the therapeutic effect

clinical symptoms

plasma motilin level and psychological state between two groups were compared. Result: The total effective rate in observation group (90%) was significantly higher than that in control group (P<0.05). The abdominal pain

abdominal distention

acid regurgitation

belching scores in observation group were (0.72±0.06)

(1.64±0.08)

(0.62±0.08) and (0.95±0.04) respectively

which were lower than control group (P<0.05). The plasma motilin of (398.68±120.14) μg · L-1 in observation group was significantly higher than control group (P<0.05). The somatization score

obsessive-compulsive symptoms score

interpersonal sensitivity score

depression symptom scores

anxiety symptoms score

hostile score

terror symptom score

paranoid symptoms score in observation group were significantly lower than those in control group (P<0.05). Conclusion: Using Banxia Xiexin decoction combined with domperidone is helpful to improving clinical symptoms

promoting level high expression of plasma motilin

alleviating negative emotions and improving effect of treatment.