Clinical Research of Chinese Medicine in Treating Patients with Type 2 Diabetes

SONG Wei; XIE Wen-wen; FAN Guan-jie; WEN Jian-xuan; ZHAO Xiao-hua

doi:10.13422/j.cnki.syfjx.2014220207

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Clinical Research of Chinese Medicine in Treating Patients with Type 2 Diabetes

更新时间：2024-01-04

- Clinical Research of Chinese Medicine in Treating Patients with Type 2 Diabetes
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 22, Pages: 207-211(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014220207
  CLC： R259
- Published：2014
- 稿件说明：
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SONG Wei, XIE Wen-wen, FAN Guan-jie, et al. Clinical Research of Chinese Medicine in Treating Patients with Type 2 Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(22): 207-211.
DOI：

SONG Wei, XIE Wen-wen, FAN Guan-jie, et al. Clinical Research of Chinese Medicine in Treating Patients with Type 2 Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(22): 207-211. DOI： 10.13422/j.cnki.syfjx.2014220207.

摘要

目的: 观察范冠杰教授经验中药治疗2型糖尿病(T2DM)的临床疗效.方法: 采用随机数字表法将符合条件的128例患者随机分为两组

治疗组予范冠杰教授治疗糖尿病经验中药方治疗

对照组予拜唐苹治疗

观察两组治疗前后体重指数(BMI)

空腹血糖(FBG)

2 h血糖(2hPBG)

糖化血红蛋白(HbA1c)

总胆固醇(TC)

甘油三酯(TG)

低密度脂蛋白胆固醇(LDL-C)

高密度脂蛋白胆固醇(HDL-C)、胰岛素曲线下面积(AUCi)

比较其临床有效性和中医证候疗效

观察两组治疗前后肝肾功能、血常规评估安全性.结果: 治疗组临床有效率为82.81%

对照组有效率为76.56%

两组差异无显著性意义.治疗组中医证候有效率为89.06%

对照组有效率为53.13%

两组差异显著(P<0.01).治疗后两组FBG

2hPBG

HbA1c均明显下降(与治疗前比较

P<0.05

P<0.01)

组间比较无显著性差异.但中药治疗组BMI

AUCi

血脂水平明显下降(与治疗前比较

P<0.05

P<0.01)

组间比较有统计学意义(P<0.05

P<0.01).对照组有16例出现不同程度的腹胀腹泻

经对症处理后症状可缓解

无需停药.治疗组无不良反应发生.结论: 范冠杰教授经验中药方治疗2型糖尿病疗效明确

且在改善临床症状、减轻体重、增加胰岛素曲线下面积、降低血脂方面有一定的积极作用

安全性佳

值得进一步推广应用.

Abstract

Objective:To observe the clinical efficacy on type 2 diabetes (T2DM) treated with professor FAN Guan-jie ' s experienced prescription of Chinese medicine . Method: One hundred and twenty-eight patients according with the diagnostic criteria were randomly divided into the control group and the treatment group by random number table. Patients in treatment group (64 cases)received the treatment of Chinese medicine and patients in control group (64 cases) received the treatment of acarbose. The body mass index (BMI)

fasting blood glucose (FBG)

two hours postprandial blood glucose (2hPBG)

glycated hemoglobin(HbA1c)

total cholesterol (TC)

triglyceride (TG)

low densith lipoprotein (LDL-C)

high density lipoprotein (HDL-C)

area under insulin curve (AUCi) were observed before and after treatment. The score of traditional Chinese medicine(TCM) symptoms and signs were compared

and the the clinical efficacy was evaluated. The safety was evaluated by hepatic and renal function

and the blood routine was examination. Result: The study found that the total effective rate was 82.81% in the treatment group and 76.56% in the control group

there was no significant difference. The total effective rate in the TCM symptoms was 89.06% and 53.13% in the control group

showing significant difference (P<0.01). After the treatment

the HbA1c

FBG

2hPBG in both groups were significant improved (P<0.05

P<0.01).The BMI

AUCi

blood fat level in the treatment group were significantly improved

as compared with that in the control grou (P<0.05

P<0.01). No adverse events were found in the treatment group. Conclusion: Professor FAN Guan-jie 's experienced prescription of Chinese medicine has chear effect in treating patients with T2DM.Besides

it is beneficial in improving the clinical symptoms

losing weight

increasing the curve area of insulin and decreasing the level of blood-lipid. Therefore

it is worthy to be applied widely in clinic.

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