Objective:To discuss the inhibition of cancerous toxin of preinvasive liver cancer (PLC) by longer-term using of Herba Hedyotis from clinical symptoms

quality of life

liver function and tumor microenvironment. Method: Seventy-five patients with PLC were randomly divided into the control group (34 cases) and the Herba Hedyotis(observation) group (41 cases) by random number table. Patients in the control group received Fufang Banmao capsules

3 capsules twice daily. Patients in the observation group received Hainan Herba Hedyotis 250-500 g fresh herb

or 60-120 g dry herb 3 or 4 times daily after decocting for two times. Patients in both groups were followed until death or for at least 6 months Cardinal symptom and signs

quality of life (Karnofsky Performance Status

KPS) were graded. Tumor respone was evaluated on the basis of solid tumor size by CT or MRI before and after treatment. Survival rates in both groups were calculated. Levels of alanine aminotransferase (ALT)

aspartate amino transferase (AST)

γ-glutamyltranspeptidase (γ-GT) and its isozyme

and alpha fetoprotein (AFP) were detected. Levels of vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) were also detected. Result: The solid tumor curative effect in observation group was superior to that in control group (P<0.05) from ordinal data card analysis. The main signs and symptoms scores in observation group were lower than those in control group

while the KPS score in observation group were higher than that in control group at the third and sixth month after treatment (P<0.05). Levels of ALT

AST and γ-GT in observation group were inferior to those in control group (P<0.05 or P<0.01). The survival rate of 58.8% in control group was lower than 80.5% in observation group during the 6 months (P<0.05). After treatment

the VEGF

TGF-βand AFP in observation group were inferior to those in control group (P<0.01). Conclusion: Long-term using of Herba Hedyotis can relieve a variety of clinical symptoms

reduce the damage to liver cells

shrink tumor mass

improve inflammatory microenvironment and inhibit tumor angiogenesis of PLC patients. Thus

the benefits in improving patients' survival rates are obtained.