Objective:To discuss recovery effect of Zhidai Huadu decoction combined with chitosan biological sponge dressing on patients after loop electrosurgical excision procedure (LEEP) and to observe its influence on local secretion of cervical such as interleukin-2 (IL-2)

interleukin-4 (IL-4)

interleukin-10(IL-10) and tumour necrosises factor-α (TNF-α). Method: One hundred and sixty patients with cervical intraepithelial neoplasia (CIN) after LEEP were randomly divided into control group (80 cases) and observation group (80 cases) by random number table. Patients in control group received externally mercurochrome on wound

orally 0.5 g azithromycin tablets once daily for 5 days

and orally 10 mL Leonurus Japonicus Houtt. Oral Liquid 3 times daily. Patients in observation group received externally of chitosan biological sponge dressing. Orally 0.5 g azithromycin tabletsonce daily for 5 days

and orally 1 dose Zhidai Huadu decoction divided twice daily. The patients in two groups received 1 8-week period of treatment. Time and volume of vaginal discharge

vaginal bleeding and intention status of wounds were recorded during the follow-up. Human papilloma virus (HPV) and desoxyribonucleic acid (DNA) in mucus and secretion around cervix were detected before and after 12 weeks of operation. Levels of IL-2

IL-4

IL-10 and TNF-α of cervical partial discharge were detected before and after 8 weeks of operation. Complications such as late hemorrhage

postoperative infection

cervical scar formation

adhesion and stenosis were recorded. Result: The curative effect of observation group was superior to that of control group (P<0.05) through ordinal data card test. The average time and amount of vaginal bleeding in observation group were less than those in control group after treatment (P<0.01). The average time and amount of vaginal discharge in observation group were less than those in control group (P<0.01). Positive rate of HPV DNA in observation group was 8.75%

which was lower than 23.75% in control group after 8-week treatment (P<0.01). Levels of IL-4

IL-10 and TNF-α in cervical partial discharge of observation group were decreased

which was obviously lower than those of control group. The level of IL-2 in observation group was increased

which was higher than that in control group after treatment (P<0.01). The cumulative incidence of complications of 7.5% in observation group was significant less than that of 27.5% in control group (P<0.01). Conclusion: Using Zhidai Huadu decoction combined with chitosan sponge dressing could reduce the average vaginal bleeding/discharge time and vaginal discharge blood/liquid volume

remove HPV residual infection

reduce complications incidence in cervical lesions patients after LEEP surgery. The action mechanism may be related to regulating imbalance of Thl/Th2 and improving antiviral ability.