Formulation Screening and Solubility Determination of Auraptene Dispersible Tablets

LI Cai-tang; YANG Li-qin; ZHANG Di; LIU Wen; YU Jin-bao

doi:10.13422/j.cnki.syfjx.2014230025

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Formulation Screening and Solubility Determination of Auraptene Dispersible Tablets

更新时间：2024-01-04

- Formulation Screening and Solubility Determination of Auraptene Dispersible Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 23, Pages: 25-27(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014230025
  CLC： R286.0
- Published：2014
- 稿件说明：
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LI Cai-tang, YANG Li-qin, ZHANG Di, et al. Formulation Screening and Solubility Determination of Auraptene Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(23): 25-27.
DOI：

LI Cai-tang, YANG Li-qin, ZHANG Di, et al. Formulation Screening and Solubility Determination of Auraptene Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(23): 25-27. DOI： 10.13422/j.cnki.syfjx.2014230025.

摘要

目的: 优化葡萄内酯分散片的制备工艺及考察其体外溶出度. 方法: 以休止角、硬度、崩解时限为指标

考察交联聚乙烯吡咯烷酮(PVPP)

微晶纤维素(MCC)、预胶化淀粉(PRS)、低取代羟丙基纤维素(L-HPC)、羧甲基淀粉钠(CMS-Na)等辅料对葡萄内酯分散片处方工艺的影响.采用HPLC测定分散片的体外溶出度

流动相甲醇-水(95:5)

检测波长325 nm. 结果: 最佳处方为葡萄内酯10 g

MCC 40 g

L-HPC 20 g

PVPP 10 g

CSM-Na 20 g

PRS 30 g

淀粉20 g;崩解时间1 min

分散均匀性好

药物30 min内累积溶出率>85%. 结论: 制备的葡萄内酯分散片具有溶散快、分散均匀、溶出速率快的特性

适用于临床应用需要.

Abstract

Objective: To optimize formulation process of auraptene dispersible tablets and evaluate its in vitro dissolution. Method: With angle of repose

hardness and disintegration time as indexes

effects of cross-linking polyvinyl pyrrolidone(PVPP)

microcrystalline cellulose(MCC)

pregelatinized starch(PRS)

low substituted hydroxypropyl cellulose(L-HPC)

sodium carboxymethyl starch(CMS-Na) and other excipients on formulation process were investigated.In vitro dissolution of dispersible tablets was determined by HPLC

mobile phase of methanol-water(95: 5)

detection wavelength was set at 325 nm. Result: Optimal formula was as follows:auraptene 10 g

MCC 40 g

L-HPC 20 g

PVPP 10 g

CSM-Na 20 g

PRS 30 g

amylum 20 g;dispersible tablets disintegrated uniformly in 1 min

cumulative dissolution of this drug was more than 85% within 30 min. Conclusion: These prepared auraptene dispersible tablets have a fast

homogeneously dispersing profile and good releasing characteristics

which is suitable for clinical application.

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Related Institution

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