Objective: To observe the effects of Wuzi Chengqi decoction on hyperuricemia rats. Method: Sixty SD male rats were divided randomly into 6 groups: normal control

model control

positive control

Wuzi Chengqi decoction high

middle and low dose groups(104

52

26 g· kg-1). The hyperuricemia rat models induced by adenine(100 mg· kg-1

ig

qd×28 d) and potassium oxonate (250 mg· kg-1

ip

qw×4weeks). High

middle and low dose groups were given Wuzi Chengqi decoction 104

52 and 26 g· kg-1

ig respectively.After 4 weeks of modeling

the rats in each group of serum uric acid (UA)

blood urea nitrogen (BUN)

serum creatinine(SCr)

xanthine oxidase (XOD)

urinary UA and renal indices were examined. Result: Compared with normal group

UA in urine was decreaed

while UA

XOD

Cre and BUN in serum were increased significantly (P<0.01). The content of urine uric acid of low

middle and high dose groups were (146.3±22.5)

(202.2±53.8)

(218.1±62.6) μmol· L-1 respectively

which was significantly higher than those of the model group (89.8±27.1)μmol· L-1(P<0.01

P<0.05). The content of serum uric acid of low

middle and high dose groups were (207.3±42.5)

(177.1±50.5)

(158.0±49.0)μmol· L-1 respectively

which was significantly lower than those of the model group(285.0±54.1)μmol· L-1(P<0.01

P<0.05).Wuzi Chengqi decoction also could significantly inhibited the serum XOD activity

decrease the content of serum SCr and BUN(P<0.01

P<0.05). Conclusion: Wuzi Chengqi decoction has good preventive and therapeutic effect on hyperuricemia rats induced by adenine and potassium oxonate.