Influence on Esophageal Motility and Acid Reflux in Patients with Gastroesophageal Reflux Disease Using Integrated Traditional Chinese Medicine and Western Medicine Therapy
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Influence on Esophageal Motility and Acid Reflux in Patients with Gastroesophageal Reflux Disease Using Integrated Traditional Chinese Medicine and Western Medicine Therapy
Chinese Journal of Experimental Traditional Medical FormulaeVol. 20, Issue 23, Pages: 205-208(2014)
ZHANG Li-xian, YUAN Shuang-zhen, CHEN Yu-mei, et al. Influence on Esophageal Motility and Acid Reflux in Patients with Gastroesophageal Reflux Disease Using Integrated Traditional Chinese Medicine and Western Medicine Therapy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(23): 205-208.
DOI:
ZHANG Li-xian, YUAN Shuang-zhen, CHEN Yu-mei, et al. Influence on Esophageal Motility and Acid Reflux in Patients with Gastroesophageal Reflux Disease Using Integrated Traditional Chinese Medicine and Western Medicine Therapy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(23): 205-208. DOI: 10.13422/j.cnki.syfjx.2014230205.
Influence on Esophageal Motility and Acid Reflux in Patients with Gastroesophageal Reflux Disease Using Integrated Traditional Chinese Medicine and Western Medicine Therapy
Objective: To discuss the influence of Qizhi Weitong granules and Muxiang Shunqi pills combined with omeprazole magnesium enteric-coated tablets and itopride hydrochloride tablets on esophageal motility and acid reflux in patients with gastroesophageal reflux disease (GERD). Method: Ninety GERD patients were randomly divided into western medicine group (45 cases) and observation group (45 cases) by random number table. Patients in western medicine group took 20 mg omeprazole magnesium enteric-coated tablets orally morning and night and 50 mg itopride hydrochloride tablets 3 times daily. Based on the treatment of western medicine group
patients in observation group added 5 g Qizhi Weitong particle 3 times daily
and 6 g Muxiang Shunqi pills 3 times daily. All patients in two groups received 8-week course of treatmen. Score of reflux disease questionnaire (RDQ) scale was recorded before and after the treatment. Esophageal manometry and 24 h esophageal pH monitoring were conducted. Result: The resting pressure of upper and lower esophageal sphincter in both groups were increased after treatment. Besides
the observation group obtained better results (P<0.01). Success rate of wet swallowing in both groups was increased as compared with that before
and the success rate in observation group was higher than that in western medicine group (P<0.01). The total number of acid reflux
the number of acid reflux>5 min
the percentage of total pH 4
the percentage of decubitus pH<4
the longest reflux time and DeMeester score in observation group were decreased after treatment (P<0.01). Besides
total number of acid reflux and DeMeester score in observation group were less than those in western medicine group (P<0.01). RDQ scale heartburn
reflux
non cardiac chest pain
anti acid score and total score in observation group were inferior to those in western medicine group (P<0.01). Conclusion: Integrated traditional Chinese medicine and western medicine therapy can strengthen function of esophageal peristalsis
improve esophageal motility
reduce acid reflux
and relieve GERD symptoms. The curative effect of this therapy is superior to using western medicine treatment alone.
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Structure-activity Omics of Traditional Chinese Medicine: A Case Study of Anti-inflammatory and Analgesic Effect of Qizhi Weitong Granules
Clinical Efficacy of Modified Chaihu Shugansan Combined with Xuanfu Daizhetang on Depression of Patients of Patients with Gastroesophageal Reflux Disease
HPLC Determination of Hesperidin in Muxiang Shunqi Pills
Related Author
MENG Xiansheng
BAO Yongrui
YANG Xinxin
WANG Shuai
SU Kaiqiang
LI Tianjiao
QI Bing
LI Tianjiao
Related Institution
College of Pharmacy, Liaoning University of Traditional Chinese Medicine (TCM)
Liaoning Multi-dimensional Analysis of TCM Technical Innovation Center
Liaoning Province Modern TCM Research and Engineering Laboratory