Influence of Shenqi Fuzheng Injection Combined with Sanshenqi Oral Liquid on Cellular Immunity Function in Cervical Cancer Patients with Postoperative Radiotherapy

HUANG Yan

doi:10.13422/j.cnki.syfjx.2014230209

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Influence of Shenqi Fuzheng Injection Combined with Sanshenqi Oral Liquid on Cellular Immunity Function in Cervical Cancer Patients with Postoperative Radiotherapy

更新时间：2024-01-04

- Influence of Shenqi Fuzheng Injection Combined with Sanshenqi Oral Liquid on Cellular Immunity Function in Cervical Cancer Patients with Postoperative Radiotherapy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 23, Pages: 209-212(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014230209
  CLC： R737.33
- Published：2014
- 稿件说明：
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HUANG Yan. Influence of Shenqi Fuzheng Injection Combined with Sanshenqi Oral Liquid on Cellular Immunity Function in Cervical Cancer Patients with Postoperative Radiotherapy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(23): 209-212.
DOI：

HUANG Yan. Influence of Shenqi Fuzheng Injection Combined with Sanshenqi Oral Liquid on Cellular Immunity Function in Cervical Cancer Patients with Postoperative Radiotherapy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(23): 209-212. DOI： 10.13422/j.cnki.syfjx.2014230209.

摘要

目的: 观察参芪扶正注射液联合三参芪口服液对宫颈癌术后放疗患者T淋巴细胞亚群、自然杀伤细胞(NK)细胞及Th1/Th2细胞的影响. 方法: 将78例患者随机按数字表法分为观察组和对照组各39例.对照组患者进行广泛性全子宫切除术

术后给予患者放化疗

钴60机全盆外照射5 000 CGy/25次

共5周;铱192腔内照射"A"点

600~700 CGy 次/周

共4 周.观察组在对照组治疗的基础上加用参芪扶正注射液

250 mL/次

静脉滴注

连续21 d为1个疗程

休息7 d后再继续下1个疗程

连续使用3个疗程.三参芪口服液

20 mL/次

2次/d

连续使用12周.两组疗程均为12周.检测治疗前后外周血T淋巴细胞亚群(CD3+

CD4+

CD8+和CD4+/CD8+)和NK水平;检测治疗前后干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)和白细胞介素-10(IL-10)水平;进行治疗前后生活质量(KPS)评分. 结果: 治疗后观察组CD3+

CD4+

CD4+/CD8+和NK细胞水平较治疗前上升(P<0.01)

并高于对照组(P<0.01)

CD8+水平较治疗前下降(P<0.01)

并低于对照组(P<0.01);治疗后观察组IFN-γ和IL-2水平高于对照组(P<0.01);观察组IL-4

IL-6和IL-10水平低于对照组(P<0.01);治疗后观察组KPS评分为(76.4±7.6)

对照组为(70.5±6.8)

观察组高于对照组(P<0.01);观察组生活质量评价有效率为87.2%高于对照组的64.1%(P<0.05). 结论: 参芪扶正注射液联合三参芪口服液能提高宫颈癌术后放化疗患者的生存质量

改善患者免疫功能

对宫颈癌治疗具有一定的优势.

Abstract

Objective: To observe the influence of Shenqi Fuzheng injection combined with Sanshenqi oral liquid on patients' T lymphocyte subsets

natural killer (NK) cells and T helper type 1 (Th1)/T helper type 2 (Th2) cells in patients with radiotherapy after cervical cancer operation. Method: Seventy-eight patients were randomly divided into control group (39 cases) and observation group (39 cases) by random number table. Patients in control group received universality hysterectomy operation

then received drill60 for entire pelvic external radiotherapy (5 000 CGy/25 times for 5 weeks) plus iridium192 for intracavitary radiotherapy to point A (600-700 CGy time/week for 4 weeks). Based on the treatment of control group

patients in observation group added Shenqi Fuzheng injection by intravenous drip (250 mL/time for 21 day periods of treatment separated by 7 days without treatment) and Sanshenqi oral liquid (20 mL/time

twice daily). All patients received 12 week period of treatment. Levels of T-lymphocyte subsets of peripheral blood (CD3+

CD4+

CD8+and CD4+/CD8+) and NK cells

and levels of interferon-γ (IFN-γ)

interleukin-2 (IL-2)

interleukin-4 (IL-4)

interleukin-6 (IL-6)

interleukin-10 (IL-10) were detected before and after the treatment. Scores of qualities of lives were graded by Karnofsky Performance Status (KPS) scale. Result: After treatment

the levels of CD3+

CD4+

CD4+/CD8+and NK cells in observation group were increased (P<0.01)

and which were higher than those in control group (P<0.01). The level of CD8+in observation group was decreased (P<0.01)

and which was lower than that in control group (P<0.01). Levels of IFN-γ

IL-2 in observation group were higher than that in control group(P<0.01). Levels of IL-4

IL-6 and IL-10 in observation group were lower than those in control group (P<0.01). KPS score in observation group was (76.4±7.6)

which was superior to that in control group (70.5±6.8) (P<0.01). The effective rate of life quality in observation group was 87.2%

which was higher than that in control group 64.1%

(P<0.05). Conclusion: Shenqi Fuzheng injection combined with Sanshenqi oral liquid can improve the life qualities of patients with radiotherapy after cervical cancer operation. Moreover

it can improve patients' immune function and there was a certain advantage in treating cancer treatment.

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