XU Wei-tong, LIU Dan, ZHENG Lu-mei, et al. Optimization of Preparation Technology of Children Anti-sweating Granules by Multi-index Comprehensive Evaluation Method[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(24): 21-23.
DOI:
XU Wei-tong, LIU Dan, ZHENG Lu-mei, et al. Optimization of Preparation Technology of Children Anti-sweating Granules by Multi-index Comprehensive Evaluation Method[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(24): 21-23. DOI: 10.13422/j.cnki.syfjx.2014240021.
Optimization of Preparation Technology of Children Anti-sweating Granules by Multi-index Comprehensive Evaluation Method
通过正交试验考察水提时间、醇沉浓度、浸膏与糊精用量比对制备工艺的影响并评价该制剂的质量. 结果: 最佳制备工艺条件为水提时间5 h
醇沉体积分数60%
清膏-糊精(1:1.5);制备的3批颗粒大小均匀
呈黄褐色
略带甜味
色泽一致
无吸潮、结块、潮解现象
溶化时间194 s
含水量4.75%
总皂苷质量分数56.13 mg·g-1. 结论: 小儿止虚汗颗粒的制备工艺稳定可行、重复性好.
Abstract
Objective: To optimize preparation process of children anti-sweating granules and provide a reference for clinical application of this preparation. Method: UV was adopted to determine the content of total saponins with detection wavelength of 541 nm.Children anti-sweating granules was prepared by extrusion granulation method
with total saponin content and dissolving time as comprehensive evaluation index
orthogonal test was adopted to optimize preparation process by taking water extraction time
alcohol precipitation concentration
ratio of dextrin-extract as factors
quality of this preparation was evaluated. Result: Optimal preparation process was as following:water extraction for 5 h
alcohol precipitation volume fraction of 60%
extract-dextrin(1:1.5);three batches of these granules had uniform particle size with brown
slightly sweet taste and consistent color
without moisture absorption
caking and deliquescence phenomenon.Dissolving time of these granules was 194 s
moisture content was 4.75%
the content of total saponins was 56.13 mg·g-1. Conclusion: This preparation process is stable
repeatable and feasible for children anti-sweating granules.
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