Objective: To prepare baicalin thermosensitive gels for external application through different mathematical models and evaluation indexes. Method: Taking poloxamer 407(P407) and poloxamer 188(P188) as gel matrices

gelation temperature was applied as a target to compare formulations of baicalin thermosensitive gels

which were optimized by all sample multiple linear regression model and central composite design-response surface methodology(CCD-RSM)

while combination of gelation time and length were adopted to optimize formulation. Result: Counting on high reliability of CCD-RSM.Gels formulation was finally confirmed as 1% baicalin

17% P407 and 1.5% P188;gelation temperature

time and length were (30.3±0.1) ℃

(18.9±1.9) s

( 0.7±0.6) cm

respectively. Conclusion: Baicalin thermosensitive gels for external application is consistent with external requests for rapid enrichment at the local and elevated compliance

index evaluation should be based on results of human determination

references are offered to filter prescriptions of external thermosensitive gels scientifically and reasonably.