Discussion on Quality Marker of Gardeniae Fructus in 2010 Edition of “Chinese Pharmacopoeia”

FU Xiao-mei; WU Jian-hua; LIU Jing; WU Zhi-gui; PEI Jian-guo; LUO Guang-ming; SUN Yan-chao; WU Guo-fang; WANG Zheng-tao

doi:10.13422/j.cnki.syfjx.2014240094

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Discussion on Quality Marker of Gardeniae Fructus in 2010 Edition of “Chinese Pharmacopoeia”

更新时间：2024-01-04

- Discussion on Quality Marker of Gardeniae Fructus in 2010 Edition of “Chinese Pharmacopoeia”
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 24, Pages: 94-97(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014240094
  CLC： R284.1
- Published：2014
- 稿件说明：
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FU Xiao-mei, WU Jian-hua, LIU Jing, et al. Discussion on Quality Marker of Gardeniae Fructus in 2010 Edition of “Chinese Pharmacopoeia”[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(24): 94-97.
DOI：

FU Xiao-mei, WU Jian-hua, LIU Jing, et al. Discussion on Quality Marker of Gardeniae Fructus in 2010 Edition of “Chinese Pharmacopoeia”[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(24): 94-97. DOI： 10.13422/j.cnki.syfjx.2014240094.

摘要

目的: 完善栀子药材的HPLC质量控制指标. 方法: 采用Agilent Zorbax SB-C18色谱柱(4.6 mm×250 mm

5 μm)

流动相乙腈(A)-0.2%磷酸溶液(B)梯度洗脱(0~15 min

6%~16%A;15~22 min

16%~21%A;22~34 min

21%~24%A;34~50 min

24%~42%A)

京尼平苷、西红花苷-1的检测波长分别为238

440 nm. 结果: 不同产地栀子中京尼平苷质量分数23.025~53.693 mg·g-1

均符合2010年版《中国药典》≥1.8%的规定;其中2批栀子的外观颜色为灰棕色、棕黄色

西红花苷-1的含量极低

分别为1.963

3.434 mg·g-1

应为不合格药材. 结论: 仅以京尼平苷作为栀子药材的质量控制指标不够合理

建议增加西红花苷-1的含量测定

为新版《中国药典》的修订提供参考.

Abstract

Objective: To improve HPLC for quality control of Gardeniae Fructus. Method: HPLC system consisted of a Agilent Zorbax SB-C18 column(4.6 mm×250 mm

5 μm) and mobile phase of acetonitrile(A)-0.2% phosphoric acid(B) with gradient elution(0-15 min

6%-16%A;15-22 min

16%-21%A;22-34 min

21%-24%A;34-50 min

24%-42%A)

monitoring wavelength was set at 238

440 nm for geniposide and crocin-1

respectively. Result: The content of geniposide in Gardeniae Fructus collected from different areas ranged from 23.025-53.693 mg·g-1

this result conformed to requirements (no less than 1.8%) in 2010 edition of “Chinese Pharmacopoeia”;but the content of crocin-1 in two samples(1.963

3.434 mg·g-1) were lower than others

color of these two samples were gray-brown and brown-yellow

them should be substandard medicine. Conclusion: The content of geniposide as only standard for quality control of Gardeniae Fructus is not rational

the content of crocin-1 should be also taken into consideration.This paper may be useful for editing the new edition of ‘Chinese Pharmacopoeia’.

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