Objective: To establish mice model of functional dyspepsia (FD) and to investigate the effects of Weiyuanning on gastrointestinal motility and gastrointestinal hormones. Method: The mice were randomly divided into normal group

model group

low-

medium-and high-dose Weiyuanning groups (22.5

45

90 g·kg-1)

and domperidone group (10 mg·kg-1). FD models were made by irregular food intake plus intraperitoneal injection with L-arginine in mice except for mice in normal group. All mice were ig administrated with corresponding medicines for 7 days. The body weights

the gastric remnant rate and small intestinal propulsion rate were measured. The gastric histopathological changes were observed. The contents of gastrin (GAS) and motilin (MTL) were detected by Elisa. Result: Compared with model group

the body weight

gastric emptying rate were decreased

the small intestinal propulsion rate was increased in model group (P<0.01). The above indexes were improved in the Weiyuanning groups (P<0.01). Meanwhile

the the contents of GAS in serum and MTL in plasma were increased in Weiyuanning groups (P<0.05

P<0.01). No significant changes were found in the improvement of gastric histopathological among all groups after the treatment. Conclusion: FD model could be successfully made by irregular food intake plus intraperitoneal injection with L-arginine. Weiyuanning has significant effect in improving indigestion in FD mice. Its mechanism may be related to elevating the levels of GAS in serum and MTL in plasma of mice.