Objective: To investigate the clinical effect of Fuzheng Xiaoliu decoction combined with paclitaxel in the treatment of advanced ovarian cancer. Method: Seventy-seven patients were divided into control group and treatment group according to their admission date (single or double date). The patients in control group received conventional treatment

and the patients in treatment group received Fuzheng Xiaoliu decoction plus paclitaxel. The changes of clinical symptoms

tumor were compared between two groups before and after treatment.The occurrence of adverse reactions were monitored. Result: Eleven patients achieved complete remission in control group

19 patients had partial remission

and 9 patients had stable disease in this study. The total effective rate in treatment group was 69.8%

which was higher than that in control group (44.1%

P<0.05). The operation time

the volume of ascites and hemorrhage in treatment group was (215.34±32.76) min

(678.35±32.32) mL and (502.89±118.53) mL

respectively

in

treatment group

which were less than that in control group (P<0.05).The incidence rate of adverse reaction was 44.19% in treatment group and 58.82% in control group with no significant difference. Conclusion: Fuzheng Xiaoliu decoction combined with paclitaxel have curative effect in treating patients with advanced ovarian cancer

which is worthy to be applied widely in clinic.