Objective: To observe the curative efficacy of Xiaopi Hewei capsules in treating precancerous lesions of gastric carcinoma (PLGC) which belonged to stagnation of liver-qi and stomach-qi

and to investigate its influence on endothelin (ET-1)

gastrin (GAS) and somatostatin (SST). Method: Sixty-four patients with PLGC were randomly divided into control group (32 cases) and observation group (32 cases) by random number table. Patients in both groups received 20 mg omeprazole magnesium enteric-coated tablets

2 bismuth potassium citrate tablets and 0.25 g clarithromycin tablet twice daily for 2 weeks. Patients in control group added 4 weifu Chun tablets thrice daily

and patients in observation group added 6 Xiaopi Hewei capsules thrice daily for 6 months. Scores of stagnation of liver-qi and stomach-qi were evaluated. Gastroscope and pathology were carried out and scores of atrophy of gastric mucous

degree of intestinal metaplasia and dysplasia were graded. Helicobacter pylori (HP) was detected. The levels of ET-1

GAS and SST were detected before and after treatment. Result: By ordinal data chi-square test

the results of gastroscopy and pathological in observation group were superior to those in control group (P<0.05). Improvement of gastric mucosa atrophy in both groups was better than before according to chi-square test (P<0.01)

while the observation group obtained better results (P<0.05). Liver-qi stagnation syndrome score in observation group was less than that in control group at the third and sixth months after treatment (P<0.01). Scores of intestinal metaplasia or (and) dysplasia in observation group were less than those in control group (P<0.01). Clearance of HP in control group was 79.2%

while the data in observation group was 84%. There was no significant difference between both groups. Infection rate of HP in control group was 40%

while the data in observation group was 17.14%. Infection rate in observation group was lower than that in control group after 6-month treatment (P<0.05). Levels of serum ET-1 and GAS in observation group were less than those in control group

SST level in observation group was higher than those in control group (P<0.01). Conclusion: Xiaopi Hewei capsules could improve clinical symptoms with PLGC patients (liver-qi stagnation syndrome)

reduce the recurrence of HP. It has certain blocking effect on the progression from PLGC to gastric cancer. Its mechanism may be related to enhancing the serum level of SST and reducing the serum levels of ET-1 and GAS.