Objective: To optimize extraction technology of Lianshen granules

in order to provide a reference for development of this preparation. Method: With yield of volatile oil as index

single factor tests were adopted to investigate effects of the amount of water

soaking time and distillation time on extraction technology of volatile oil in Angelicae Sinensis Radix

Cinnamomi Cortex and Magnoliae Flos.UV was adopted to determine the content of total alkaloids with detection wavelength of 350 nm.The content of berberine hydrochloride was determined by HPLC

which used acetonitrile-0.05 mol·L-1 potassium dihydrogen phosphate(50:50) as mobile phase

detection wavelength was 345 nm.With contents of berberine hydrochloride and total alkaloids

yield of dry extract as comprehensive evaluation index

effects of the amount of water

extraction time and times on water extraction technology of Lianshen granules was investigated by orthogonal test. Result: Optimum extraction technology of volatile oil was as following:soaked one hour with eight times the amount of water

then distilled five hours.Optimum water extraction technology conditions were as follows:boiled herbs with eight times the amount of water for thrice

one hour for each time.Dry extract yield was 25.91%

extraction amounts of total alkaloids and berberine hydrochloride were 512.34

130.81 mg

respectively. Conclusion: Optimized extraction technology is simple

stable and feasible

which is suitable for industrial production of Lianshen granules.