Simultaneous Quantitative Determination of Ginsenosides Re, Rg, Rb and Notoginsenoside R in Fufang Danshen Tablets by QAMS

GENG Yan-na; ZHANG Wen-xin

doi:10.13422/j.cnki.syfjx.2015010069

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Simultaneous Quantitative Determination of Ginsenosides Re, Rg, Rb and Notoginsenoside R in Fufang Danshen Tablets by QAMS

更新时间：2024-01-04

- Simultaneous Quantitative Determination of Ginsenosides Re, Rg, Rb and Notoginsenoside R in Fufang Danshen Tablets by QAMS
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 1, Pages: 69-72(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015010069
  CLC： O657.72;R286.0
- Published：2015
- 稿件说明：
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GENG Yan-na, ZHANG Wen-xin. Simultaneous Quantitative Determination of Ginsenosides Re, Rg, Rb and Notoginsenoside R in Fufang Danshen Tablets by QAMS[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(1): 69-72.
DOI：

GENG Yan-na, ZHANG Wen-xin. Simultaneous Quantitative Determination of Ginsenosides Re, Rg, Rb and Notoginsenoside R in Fufang Danshen Tablets by QAMS[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(1): 69-72. DOI： 10.13422/j.cnki.syfjx.2015010069.

摘要

目的: 建立复方丹参片中人参皂苷Rg1

Rb1和三七皂苷R1的“一测多评”含量测定方法。方法: 以人参皂苷Rb1为内标

采用RP-HPLC法建立其与人参皂苷Rg1

Re和三七皂苷R1的相对校正因子

运用该校正因子计算出人参皂苷Rg1

Re和三七皂苷R1的含量。运用外标法测定这4个成分的含量

并比较两种方法测定结果。结果: 建立了“一测多评”测定复方丹参片中人参皂苷Rg1

Rb1和三七皂苷R1含量的方法。外标法和“一测多评”法测定含量的结果无显著性差异。结论: “一测多评”的方法快速和准确

且节约对照品资源

能运用于复方丹参片的质量控制。

Abstract

Objective: To establish a quantitative determination of ginsenosides Rg1

Rb1 and notoginsenoside R1 in Fufang Danshen tablets based on the quantitative analysis of multi-components by single marker (QAMS). Method: RP-HPLC method was used ginsenoside Rb1 as internal reference standard

and 3 relative correction factors (RCF) to ginsenoside Rb1 were calculated. The contents of ginsenosides Rg1

Rb1 and notoginsenoside R1 in Fufang Danshen tablets were determined by both external standard method and QAMS. The differences between the two methods were evaluated. Result: A QAMS method for simultaneous determination of ginsenosides Rg1

Rb1 and notoginsenoside R1 in Fufang Danshen tablets has been established. No significant differences were found in the quantitative results of ginsenosides Rg1

Rb1 and notoginsenoside R1 in Fufang Danshen tablets determined by the two methods. Conclusion: The QAMS method is rapid

accurate

and can save reference substances. QAMS is suitable for quality control of Fufang Danshen tablets.

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