DONG Kai-zhong, GAO Yong-sheng, QIN Ning-en-jia, et al. Effects of Senlin Baishu San on the Dysbacteriosis Induced by Antibiotics in Mices[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(1): 154-157.
DOI:
DONG Kai-zhong, GAO Yong-sheng, QIN Ning-en-jia, et al. Effects of Senlin Baishu San on the Dysbacteriosis Induced by Antibiotics in Mices[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(1): 154-157. DOI: 10.13422/j.cnki.syfjx.2015010154.
Effects of Senlin Baishu San on the Dysbacteriosis Induced by Antibiotics in Mices
Objective: To investigate the effect of Shenlin Baishu San on the dysbacteriosis induced by antibiotics in mice. Method: The healthy SPF BALB/c mice were divided into the normal group
the model control group
the Peifeikang group (0.1 g·kg-1) and the low-
medium-
high-dose Shenlin Baishu San groups (0.1
0.2
0.4 g·kg-1). Dysbacteriosis models were induced by antibiotics ceftriaxone sodium solution for 5 days. After 7-day treatment
changes of intestinal flora with sterile take feces were observed using plate dilution method (each intestinal bacteria number was trained). Serum immunoglobulin G (IgG)
endotoxin
vasoactive intestinal peptide (VIP) and substance P (SP) content were measured using enzyme linked immunosorbent assay. Result: The number of probiotics in the model group was signifigantly decreased as compared with that in the normal group (P<0.01). Serum levels of endotoxin and SP were significantly higher. serum IgG and VIP were significantly lower in model group than those in control group (P<0.01). The bacteria number
endotoxin
VIP and SP were decreased
serum IgG was increased in all dosages of Shenlin Baishu San groups
there was statistically significant difference as compared with model group (P<0.05
P<0.01). Conclusion: Shenlin Baishu San could regulate the balance of intestinal flora effectively.
Effect and Mechanisms of Chinese Medicine and Its Active Ingredients in Enhancing Antibacterial Activities of Antibiotics: A Review
Banxia Xiexintang and Its Disassembled Prescriptions Regulate Colonic Mucosal Immunity in Young Rats with Flora Disorder
Overview of Experimental Methods for Antimicrobial Activity of Natural Drugs
Research Strategy of Mechanism of Efficacy Enhancing and Toxicity Reducing of Antibiotics Combined with Chinese Medicine for Infectious Diseases
Influence of the Compound Qingre Granule-Serum on Bacteria Resistance under Antibiotics of Low Concentration
Related Author
KUANG Sufang
YUAN Tao
JIANG Xueqin
CHEN Ling
Zhong-bo ZHU
Li-juan SHI
Jin-duo ZHANG
Pei-qing LI
Related Institution
Jiangxi Provincial Key Laboratory of Natural and Biomimetic Drugs Research, School of Health, Jiangxi Normal University
Department of Medicine,China National Intellectual Property Administration
Gansu Engineering Laboratory for New Products of Traditional Chinese Medicine (TCM), Gansu Key Laboratory of TCM Excavation and Innovative Transformation,Gansu University of Chinese Medicine
The First Hospital of Lanzhou University
Tianjin University of Traditional Chinese Medicine