Objective: To observe the antitumor effects of different polarity extracts from Kaki Folium on hepatoma H22 and sarcoma S180 bearing mice. Method: The the Kaki Folium were successively extracted with ethanol

chloroform

ethyl acetate and n-butanol

the ethanol extraction were extracted by water

and the different polarity extracts were obtained. Experimental H22 ascites tumor mice model

H22 and S180 solid tumor mice models were established

respectively. The experimental mice were randomly divided into a series of groups:blank control group

model group

cyclophosphamide group

low-

middle-and high-dosage groups of the various different polarity extracts. The mice were intragastrically administrated the corresponding drugs for 10 days. The abdominal circumference

inhibition rate of ascites and liver tissue physiological form were observed in H22 ascites tumor mice. The food intake

body weight

tumor inhibition rate

life prolongation rate

values of thymus coefficient and spleen coefficient were recorded. Result: Compared with the model group

the volume of ascites and ameliorate liver cell swelling

karyolysis on H22 ascites tumor mice were significantly reduced in ethyl acetate extract

water extract and n-butanol extract groups

while no significant effects on food intake and body weight in H22

S180solid tumor mice were found. The tumor inhibition rate

life prolongation rate

values of thymus coefficient and spleen coefficient were significantly increased (P<0.01 or P<0.05) after treated with different polarity extracts and cyclophosphamide groups. Conclusion: The ethyl acetate extract

water extract and n-butanol from Kaki Folium possess have certain antitumor effects on hepatoma H22 and sarcoma S180 bearing mice

which may be the effective fractions of antitumor effects from persimmon leaves. The ethyl acetate-extracted fraction has better effects on hepatoma H22 bearing mice (included the solid and ascites tumor) than sarcoma S180 bearing mice.