Comparison of Voix Pedis Swelling Effects of Brucine on Adjuvant-induced Arthritis Rats Before and After Inclusion of Brucine-hydroxypropyl--cyclodextrin
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Comparison of Voix Pedis Swelling Effects of Brucine on Adjuvant-induced Arthritis Rats Before and After Inclusion of Brucine-hydroxypropyl--cyclodextrin
Chinese Journal of Experimental Traditional Medical FormulaeVol. 21, Issue 1, Pages: 174-177(2015)
ZHENG De-jun, PAN Ya. Comparison of Voix Pedis Swelling Effects of Brucine on Adjuvant-induced Arthritis Rats Before and After Inclusion of Brucine-hydroxypropyl--cyclodextrin[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(1): 174-177.
DOI:
ZHENG De-jun, PAN Ya. Comparison of Voix Pedis Swelling Effects of Brucine on Adjuvant-induced Arthritis Rats Before and After Inclusion of Brucine-hydroxypropyl--cyclodextrin[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(1): 174-177. DOI: 10.13422/j.cnki.syfjx.2015010174.
Comparison of Voix Pedis Swelling Effects of Brucine on Adjuvant-induced Arthritis Rats Before and After Inclusion of Brucine-hydroxypropyl--cyclodextrin
Objective: To compare effects of brucine and brucine-hydroxypropyl-β-cyclodextrin(bru-HP-β-CD) inclusion complex on adjuvant-induced arthritis rats
in order to provide a reference for development of this preparation. Method: After being modeled with Freund's complete adjuvant
effects of brucine and bru-HP-β-CD inclusion complex on pharmacological indexes of adjuvant arthritis rats were detected
including primary and secondary voix pedis swelling
pain threshold
weight and so on. Result: Compared with the model group
brucine group and bru-HP-β-CD inclusion complex group could significantly increase pain threshold and reduce voix pedis swelling.Analgesic effect was the best after proinflammatory for 0.5 h by brucine
its anti-inflammatory effect for primary disease after 48 h was the most significant;however
analgesic effect was optimum after proinflammatory for 1.0 h by bru-HP-β-CD inclusion complex
its anti-inflammatory effects were better than those of brucine group for primary disease after 72 h and secondary disease after 24 d. Conclusion: Anti-inflammatory effect of brucine is rapid action
but effect of bru-HP-β-CD can maintain for a long time and is better than brucine.Brucine can effectively relieve joint pain of rats with adjuvant-induced arthritis after being included by HP-β-CD
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Related Author
RAO Tao
LI Dong-xun
HE Xiu-ju
FENG Yu-lin
LUO Xiao-jian
LI Ning
WANG Xue-ting
JIANG Shao-hong
Related Institution
School of Pharmacy, The Second Affiliated Hospital, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine
School of Pharmaceutical Sciences, Zhengzhou University
The First Affiliated Hospital of Zhengzhou University
School of Basic Medical Sciences, Guizhou Medical University
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences