Objective: To discuss the influence of Shenhe Zhigan decoction on sugar

lipid and uric acid metabolism in treating patients with nonalcoholic fatty liver disease (NAFLD) (liver stagnation and spleen deficiency combined with phlegm and blood stasis) and to discuss its resistance to oxidative stress. Method: One hundred and sixteen patients with NAFLD were randomly divided into control group (58 cases) and observation group (58 cases) by random number table. Patients in both groups received orally 10 mg vitamin E thrice daily

and 10 mg simvastatin tablets once daily. Patients in control group added orally 2 Xuezhikang tablets twice daily

and patients in observation group added 1 does Shenhe Zhigan decoction once daily for 12 weeks. Liver and spleen CT ratio were evaluated before and after treatment. Levels of triglyceride (TG)

total cholesterol (TC)

high-density lipoprotein (HDL-C)

low density lipoprotein (LDL-C) and blood uric acid (SUV) were tested before and after treatment. Fasting blood glucose (FBG)

fasting insulin (FINS) were detected and indexe of insulin resistance (HOMA IR) was calculated. Levels of superoxide dismutase (SOD) and malondialdehyde (MDA) were tested before and after therapy. Result: ① Fatty liver curative effects the improvement of liver/spleen CT ratio in observation group was superior to that in control group (P<0.05) by the chi-square test order data. Besides

curative effect of fatty liver in observation group was better than that in control group (P<0.05). ②Influence of sugar

lipid and uric acid metabolism TG and TC levels in observation group were lower than those in control group (P<0.01). Abnormal cases of TG and TC in observation group were less than those in control group (P<0.05). FINS and IR levels in observation group were lower than thoses in control group (P<0.01). Level of SUV in observation group was inferior to that in control group (P<0.01). ③Resistance to oxidative stress Level of SOD in observation group was higher than that in control group

while the MDA level in observation group was less than that in control group (P<0.01). Conclusion: Shenhe Zhigan decoction could regulate the metabolism of sugar

lipid and uric acid in NAFLD patients (liver stagnation and spleen deficiency combined with phlegm and blood stasis)

and improve the IR index. It has a certain resistance to oxidative stress and has a good effect in treating NAFLD as compared with Xuezhikang.