Effects of Chaixie Danshen Decoction on Inflammatory Cytokines in Unstable Angina Pectoris Patients of Qi Stagnation and Blood Stasis Type

HUANG Liu-xiang; CHENG Chou-fu; WANG Min

doi:10.13422/j.cnki.syfjx.2015010191

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Effects of Chaixie Danshen Decoction on Inflammatory Cytokines in Unstable Angina Pectoris Patients of Qi Stagnation and Blood Stasis Type

更新时间：2024-01-04

- Effects of Chaixie Danshen Decoction on Inflammatory Cytokines in Unstable Angina Pectoris Patients of Qi Stagnation and Blood Stasis Type
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 1, Pages: 191-194(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015010191
  CLC： R285.6
- Published：2015
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HUANG Liu-xiang, CHENG Chou-fu, WANG Min. Effects of Chaixie Danshen Decoction on Inflammatory Cytokines in Unstable Angina Pectoris Patients of Qi Stagnation and Blood Stasis Type[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(1): 191-194.
DOI：

HUANG Liu-xiang, CHENG Chou-fu, WANG Min. Effects of Chaixie Danshen Decoction on Inflammatory Cytokines in Unstable Angina Pectoris Patients of Qi Stagnation and Blood Stasis Type[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(1): 191-194. DOI： 10.13422/j.cnki.syfjx.2015010191.

摘要

目的: 探讨柴蝎丹参汤治疗气滞血瘀型不稳定型心绞痛的疗效及对炎症细胞因子高敏C-反应蛋白(hs-CRP)

肿瘤坏死因子-α(TNF-α)

白细胞介素-6(IL-6)

基质金属蛋白酶-9(MMP-9)的影响

探讨柴蝎丹参汤治疗不稳定型心绞痛的可能机制。方法: 82例气滞血瘀型不稳定型心绞痛患者随机分为观察组42例及对照组40例

对照组给予常规西药治疗

观察组在此基础上加用柴蝎丹参汤治疗

疗程均为6周。观察两组临床疗效和治疗前后中医症状积分的变化

以及两组治疗前后血清hs-CRP

TNF-α

IL-6

MMP-9水平变化情况。结果: 观察组总有效率为90.48%优于对照组的70.00%(P<0.05);两组患者治疗后胸痛、胸闷、心悸、气短等中医症状单项评分及总积分均降低

而观察组下降幅度较对照组明显(P<0.01);观察组中医证候有效率92.86%优于对照组的67.50%(P<0.05);两组治疗后血清hs-CRP

TNF-α

IL-6

MMP-9水平均显著降低(P<0.05

P<0.01)

观察组降低的幅度明显大于对照组(P<0.05)。结论: 柴蝎丹参汤能有效地改善气滞血瘀型不稳定型心绞痛临床症状;能明显降低患者血清中hs-CRP

TNF-α

IL-6

MMP-9水平

提示柴蝎丹参汤可能通过调控炎症细胞因子的水平起到抗炎、抗AS作用。

Abstract

Objective: To investigate the clinical efficacy and the possible mechanisms of Chaixie Danshen decoction in treating unstable angina pectoris (UAP) patients of Qi stagnation and blood stasis type. Method: Eighty-two patients with UAP were randomly divided into observation group (42 cases) and control group (40 cases). Patients in both groups received conventional western medical treatment

and patients in observation group added Chaixie Danshen decoction. All patients received 6 weeks of treatment. The clinical efficacy and the change of Chinese medical syndrome between the two groups were compared before and after treatment. The serum levels of high-sensitivity C-reactive protein (hs-CRP)

tumor necrosis factor alpha (TNF-a)

interleukin 6 (IL-6) and matrix metalloproteinase-9 (MMP-9) were observed before and after treatment. Result: The total curative rate of the observation group (90.48%) was better than that (70.00%) of the control group (P<0.05). The total scores of Chinese medical syndrome and the single score for chest pain

chest tightness

breathe hard

palpitations after treatment were lower than those before treatment in two groups;score changes in observation group were superior to that in control group (P<0.01). The effective rate of Chinese medical syndrome in the observation group (92.86%) was better than that (67.50%) in the control group (P<0.05). Compared with before

the levels of hs-CRP

TNF-α

IL-6 and MMP-9 were significantly decreased in two groups (P<0.05 or P<0.01)

and the observation group obtained better results (P<0.05). Conclusion: Chaixie Danshen decoction could improve symptoms in UAP patients of Qi stagnation and blood stasis type and reduce the levels of hs-CRP

TNF-α

IL-6 and MMP-9.These findings indicate that Chaixie Danshen decoction may have anti-inflammation and anti-atherosclerosis by regulating the levels of inflammatory cytokines of patients with UAP.

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