By reviewing the literatures in recent years

the latest progress on chemical components

pharmacology

toxicity studies and metabonomics of Toosendan Fructus have been arranged and analysed. The previous researchs have shown that toosendanin

isolated from Toosendan Fructus

have certain toxicity. The summary not only illustrated the compatibility attenuated mechanism of Toosendan Fructus based on absorption and metabolism

but also revealed its rational and scientific connotations of compatibility. As a traditional Chinese herb Toosendan Fructus has been extensively applied in clinics. However

the current researchs about pharmacological effect of Toosendan Fructus are focused on its neem alkyl-type triterpenoids and limonoids compounds. So far

there is limited systemic research on therapeutic material basis of Toosendan Fructus. In order to ensure its safe and effective application in clinics

the therapeutic basis in vivo should be seeked by comprehensive analysis using serum chemistry combined PK/PD studies.