Objective: To study materiomic of release kinetics and dissolution characteristics of Liuwei Dihuang pills and correlation of them. Method: Choosing Liuwei Dihuang pills from three manufacturers and different batches produced by manufacturer A. According to Chinese Pharmacopia

using the evaluation methods of release kinetics of traditional Chinese Medicine to determining the materiomics release kinetics and the release characteristic of Liuwei Dihuang pills by the paddle method

determining the dissolution time

and analyzing the correlation between the characteristic parameter of drug release and dissolution of Liuwei Dihuang pills. Result: T50 of Liuwei Dihuang pills of the three manufacturers are 107.01

134.33

and 13.01 min

respectively while Td are 234.11

385.42

and 206.17 min. The materiomic release kinetics had significant difference among three different manufacturers (P<0.01);T50 of Liuwei Dihuang pills of three different batches produced by manufacturer A are 107.01

125.93

194.44 min and Td of them are 234.11

385.42

206.17 min. The materiomic release kinetics had significant difference among different batches produced by manufacturer A (P<0.01). Their disintegration time are 32

43

37

35

21 min

there was high lever of linear correlation between the release curve fitting parameter as T50

Td and disintegration time trials result (P<0.05). Conclusion: There were significant difference among Liuwei Dihuang pills of different manufacturers or different batches produced by manufacturer A under the evaluation methods of materiomic release kinetics. And the release rate has correlation with the disintegration time.