CUI Jun, LIU Xing-xing, LI Yue-ting, et al. Comparison of Effects and HPLC Detection on Different Extracts of Miao Medicine in Guizhou Province[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(2): 53-56.
DOI:
CUI Jun, LIU Xing-xing, LI Yue-ting, et al. Comparison of Effects and HPLC Detection on Different Extracts of Miao Medicine in Guizhou Province[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(2): 53-56. DOI: 10.13422/j.cnki.syfjx.2015020053.
Comparison of Effects and HPLC Detection on Different Extracts of Miao Medicine in Guizhou Province
anti-inflammatory and anti-nociceptive effects of 70% ethanol extract (E70%EtOH) and water extract (Ewater) of Oxalis corniculata
HPLC was used to analyze figure information and determine the best extrat. Method: The maximum dosage test was used to evaluate safety of E70%EtOH and Ewater. Permeability increasion of celiac capillary induced by glacial acetic acid in mice was performed to investigate the anti-inflammatory effect
writhing test induced by glacial acetic acid in mice was used to observe the anti-nociceptive activity. Analyze different extracts by HPLC. Result: E70%EtOHand Ewater didn't show toxicity in the range of 35 to 1 120 mg · kg-1
MTD>1 120 mg · kg-1. Compare with Ewater
E70%EtOH could remarkable inhibit the permeability increasion of celiac capillary and the writhing reaction in mice
HPLC peak information is richer and the common peak ratio is higher than that of Ewater. Conclusion: Lethal dose of E70%EtOH and Ewater may be very high and toxicity of E70%EtOH and Ewater may be very low. The effects of E70%EtOH is better than that of Ewater
E70%EtOH can more fully the enrichment of active component.