SHI Cong, ZHANG Lan-chun, YU Xiao-ling, et al. Preparation and Wound Tissue Repair Action of Dragon's Blood Gel[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(2): 156-160.
DOI:
SHI Cong, ZHANG Lan-chun, YU Xiao-ling, et al. Preparation and Wound Tissue Repair Action of Dragon's Blood Gel[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(2): 156-160. DOI: 10.13422/j.cnki.syfjx.2015020156.
Preparation and Wound Tissue Repair Action of Dragon's Blood Gel
Objective: To prepare the dragon's blood gels and to investigate its effect of wound tissue repair in mice. Method: The orthogonal experiment was designed with carbomer concentration
propylene glycol volume and pH value as factors
the appearance
irritation
thermostability
chill stability and centrifug stabiity as evaluation index to optimize the best formula of dragon's blood gels. Thirty mice were randomly divided into 3 groups
the model group (gels base)
the observation group (dragon's blood gels) and the positive drug group (clindamycin lidocaine gels). The trauma was made by cuting a size of the diameter of 1.2 cm wound in the back of the mice. The wound changes at different time points were observed and the histopathological score of wound biopsy was evaluated. Result: The preparation of dragon's blood gel was optimized as follows:0.5% Carbomer-940
2.5 mL Propylene glycol and adjusting pH to 8.0.The product displayed a predominant spread property with uniform appearance and color. No changes of product were observed after the thermostability
chill stability and eentrifug stabiity tests. The mice tests showed that the wound surface was more smooth and neat
and the heal time was shorter in the dragon's blood gels and positive drug groups than those in the model group with significiant difference (P<0.05). Conclusion: The preparation technology of dragon's blood gels is simple and the gel has good stability. Morever
the dragon's blood gels could promote the tissue repair in mice.
Establishment and Evaluation of Mouse Model of Ischemic Heart Disease with Qi and Yin Deficiency Syndrome Based on Proteomics
Comprehensive Application of AHP-CRITIC Hybrid Weighting Method, Grey Correlation Analysis and BP-ANN in Optimization of Extraction Process of Qizhi Prescription
Construction of ATMT System for Clonostachys rosea and Its Conditional Optimization of Colonization into Glycyrrhiza uralensis Seeds
Optimization of Extraction and Purification Process of Total Iridoids and Total Crocins in Gardeniae Fructus
Related Author
XU He
DAI Ling
SHEN Cheng-ying
BAI Jin-xia
SHEN Bao-de
YUAN Hai-long
ZHANG Qiuyan
LI Ying
Related Institution
Natural History Museum of China
Beijing Key Laboratory of Chinese Materia Pharmacology,Institute of Basic Medical Sciences, Xiyuan Hospital,China Academy of Chinese Medical Sciences
Beijing University of Chinese Medicine
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
School of Chinese Materia Medica, Beijing University of Chinese Medicine