Objective: To observe the effect of Lantana camara on ulcerative colitis rats. Method: Forty\|eight rats were randomly divided into 6 groups:normal group

model group

salazosulfapyridine(SASP

0.3 g · kg-1)group

L. camara low

middle and high dose groups(12

6

3 g · kg-1). Ulcerative colitis model was copied by 2

4

6-trinitrobenzenesulfonic acid(TNBS). After 10 days' treatment

the changes of colonic mucosal damage index (CMDI)

histopathological score (HS)

serum levels of tumor necrosis factor-α (TNF-α)

interleukin-1β (IL-1β)

interleukin-4 (IL-4) and interleukin-10 (IL-10) were observed. Result: Compared with normal group

the CMDI and HS of model group were significantly increased(P<0.01);compared with model group

the CMDI and HS of middle-and high-dose L.camara groups and SASP group decreased significantly(P<0.05 or P<0.01);there was no significant difference in CMDI and HS among L.camara groups and SASP group. Compared to normal group

the serum TNF-α and IL-1β levels of model group increased significantly(P<0.01)

while the IL-4 and IL-10 levels decreased significantly(P<0.01).The serum TNF-α and IL-1β levels level of treatment groups decreased significantly(P<0.01). Compared with model group

while the IL-4 and IL-10 levels increased significantly(P<0.01).Compared with SASP group

the serum TNF-α level of low-dose L.camara group increased significantly (P<0.01);the serum IL-1β level of high and middle dose L.camara groups decreased significantly(P<0.01)

while the serum IL-10 level of these two groups increased significantly (P<0.05);the IL-4 level of low-dose L. camara group decreased significantly(P<0.05). Conclusion: L.camara treated UC rats effectively

probably by regulating the balance of pro-and anti-inflammatory cytokines.