Objective: To observe the effects of Xuefu Zhuyu Tang on cardiac function

cardiac muscle and blood vessel in rabbits with coronary heart disease at stage of blood stasis syndrome. Method: Thirty-six healthy rabbits were randomly divided into normal group

sham-operation group

model group

and Xuefu Zhuyu Tang low-dose

middle-dose

high-dose groups six groups with six rabbits in each group. Left coronary artery implanted constrictor ring to establish the model of coronary heart disease at the stage of blood stasis syndrome. The sham-operation group was just opened the chest but not implanted the constrictor ring. On the basis of the model group from the first day of the fourth week after operation the low-dose

middle-dose

high-dose groups were respectively intragastric administrated(ig) with Xuefu Zhuyu Tang according to 10

20

40 g · kg-1

once a day for continuous five weeks while the control group

the model group and the sham-operation group were ig the same volume normal saline. Then to detect the cardiac function

heart index

the levels of vasoactive factors and observe pathological change pictures of cardiac muscle and blood vessel. Result: Compared with the normal group

in the model group cardiac function declined

heart index increased

the levels of angiotensis Ⅱ(AngⅡ)

tumor necrosis factor-α(TNF-α)

reactive oxygen species(ROS) while the level of nithic oxide(NO) reduced(P<0.05

P<0.01)

meantime

in the model group there were pathological changes of cardiac muscle and blood vessel. Compared with the model group

all of the low-dose

middle-dose

high-dose groups could improve cardiac function

inhibit the pathological changes of cardiac muscle and blood vessel and restore the normal levels of vasoactive factors

which had a statistical significance (P<0.05

P<0.01). Conclusion: It was included that Xuefu Zhuyu Tang improved the pathological changes of cardiac muscle and blood vessel and restored the cardiac function by alleviating the oxidative injury of coronary artery.