Objective: To observe the curative efficacy of Huadu Yuyang decoction in treating mild and and moderate ulcerative colitis (UC) and to investigate its influence on interleukin-1

4

10(IL-1

4

10) and tumor necrosis factor-α (TNF-α). Method: Eighty-five patients with mild and and moderate UC in active stage were randomly divided into control group (42 cases) and observation group (43 cases) by random number table

and another 15 patients were assigned as healthy control. Patients in both groups received orally sulfasalazine enteric-coated tablets and prednisone. Patients in control group received mesalazine enemas

patients in observation group received retention enema of Huadu Yuyang decoction for 5 days in a week. Patients in two groups received 8 weeks of treatment. Scores of syndome of dampness-heat in large intestine and disease activity were graded

colonoscopy test was detected

and levels of serous IL-1

4

10 and TNF-α were detected before and after treatment. Result: The clinical effect in observation group was superior to that in control group (P<0.05). The syndrome of dampness-heat in large intestine

colonoscopy scores and the Mayo scores in observation group were less than those in control group (P<0.01).Levels of serum TNF-α and IL-1 were obviously higher (P<0.01)

IL-4 and IL-10 levels were significantly lower in two groups than those in healthy control groups before treatment (P<0.01). After treatment

levels of serum TNF-α and IL-1 in observation group were lower than those in control group (P<0.01). There was no statistically significant difference for TNF-α level between observation group and healthy control group. IL-4 and IL-10 levels in observation group were superior to those in control group (P<0.01). Conclusion: Huadu Yuyang decoction retention enema could improve clinical symptoms

control activities

and promote the healing of mucosa ulcer in UC patients at mild and moderate stage. Its mechanism may be related to promoting the inflammatory cytokines/suppression of inflammatory cytokines balance and reducing intestinal inflammation of UC.