Process Screening and Mechanism Analysis of Lactose Micropowder Grinding Modification to Decrease Hygroscopicity of Angelicae Dahuricae Radix Extract

ZHANG Fang; HAN Li; ZHANG Ding-kun; YANG Ying-guang; TANG Yi-xuan; WU Zhen-feng; YANG Ming

doi:10.13422/j.cnki.syfjx.2015030006

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Process Screening and Mechanism Analysis of Lactose Micropowder Grinding Modification to Decrease Hygroscopicity of Angelicae Dahuricae Radix Extract

更新时间：2024-01-04

- Process Screening and Mechanism Analysis of Lactose Micropowder Grinding Modification to Decrease Hygroscopicity of Angelicae Dahuricae Radix Extract
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 3, Pages: 6-9(2015)
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- DOI：10.13422/j.cnki.syfjx.2015030006
  CLC： R283.6
- Published：2015
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ZHANG Fang, HAN Li, ZHANG Ding-kun, et al. Process Screening and Mechanism Analysis of Lactose Micropowder Grinding Modification to Decrease Hygroscopicity of Angelicae Dahuricae Radix Extract[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(3): 6-9.
DOI：

ZHANG Fang, HAN Li, ZHANG Ding-kun, et al. Process Screening and Mechanism Analysis of Lactose Micropowder Grinding Modification to Decrease Hygroscopicity of Angelicae Dahuricae Radix Extract[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(3): 6-9. DOI： 10.13422/j.cnki.syfjx.2015030006.

摘要

目的: 筛选乳糖微粉研磨改性降低白芷提取物吸湿性的工艺条件

分析乳糖微粉的抗吸湿机制。方法: 以吸湿率为评价指标

采用单因素试验考察乳糖种类、药辅比、研磨时间对乳糖微粉研磨改性以降低白芷提取物吸湿性的工艺条件

通过粒径分布、微观结构等物理指标对改性物加以佐证。结果: 乳糖微粉研磨改性最佳工艺条件为白芷提取物与乳糖超微粉(粉碎1 min)等比例研磨3 min。改性物的粒径d0.1

d0.5

d0.9分别为3.477

15.078

54.501 μm

接触角(7.7±0.66)度

乳糖颗粒包覆在白芷提取物表面。结论: 乳糖适度微粉化能明显降低白芷提取物的吸湿初速度与吸湿加速度的绝对值

能显著降低白芷提取物的吸湿性。抗吸湿作用可能与研磨改性使得乳糖粒子附于白芷提取物表面密切相关。

Abstract

Objective: To screen technological conditions of lactose micropowder grinding modification to decrease hygroscopicity of Angelicae Dahuricae Radix(ADR) extract and analyze anti-absorption mechanism of lactose micropowder. Method: With moisture absorption rate as index

single factor test was adopted to investigate effects of kinds of lactose micropowder

ratio of raw materials to accessories and grinding time on technological conditions of lactose micropowder grinding modification

modifiers were supported by physical indexes

such as particle size distribution

microstructure and so on. Result: Optimal technological conditions of lactose micropowder grinding modification to decrease hygroscopicity of ADR extract were as follows:ARD extract-lactose micropowder(crushed 1 min) of 1:1

grinding time of three minutes.Particle sizes d0.1

d0.5 and d0.9 of modifier were 3.477

15.078

54.501 μm

respectively.The contact angle was (7.7±0.66) °

surface of ARD extract was coated by lactose micropowder particles. Conclusion: Available micronizing lactose can significantly decrease absolute values of initial velocity and acceleration of moisture absorption of ADR extract for reducing its hygroscopicity.Possibility of anti-absorption effects is that lactose particles are attached to surface of ADR extract after grinding modification.

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