Objective: To investigate the excretion kinetics of the effective components of ligustilide

butylphthalide and senkyunolide A in supercritical CO2 extraction part after oral administration of Xiongqiong Tang in rats. Method: The urine and feces samples of rats were collected according to different time periods after oral administration

the concentration of the above three compounds were determined by HPLC

the excretion curves were established and the excretion characteristics were studied using 3P 97 pharmacokinetic software. Result: The excretion curves showed that the urinary excretion rate of ligustilide increased gradually from 0 to 24 h

and then decreased after that

while in the feces the excretion rate of ligustilide approached the maximum from 36 h to 48 h and decreased whereafter;the urinary excretion rate of butylphthalide approached to the maximum gradually from 12 h to 48 h;the excretion rate of senkyunolide A in feces approached the maximum from 12 h to 48 h. Conclusion: The cumulative excretion-time curves and the average excretion rate-time curves of ligustilide are in accordance with butylphthalide in urine

so are the ligustilide and senkyunolide A in feces

which reflectes a kind of common excretion characteristics. These findings provide reference for investigating the integral excretion pattern of Xiongqiong Tang.