Objective: To discuss the curative efficacy of Xiaoke Tongguan decoction (XTD) combined conventional western medicine therapy in treating diabetes united coronary heart disease and to explore its influence on high mobility group protein B1 (HMGB 1) and serum retinal element 1 level. Method: Ninety-two patients were randomly divided into the control group (46 cases) and the combination group (46 cases) by random number table. Patients in the control group received western medicine comprehensive treatment including controlling blood glucose and blood pressure

aspirin enteric-coated tablets

0.1 g

once daily

metoprolol tartrate tablets

50 mg

once daily

simvastatin tablets

10 mg

once daily and nitroglycerin tablets

0.5 mg

sublingually taken when necessary. Based on the treatment in the control group

patients in the combination group added XTD

1 does daily. All patients received 3-month treatment. Levels of fasting blood glucose (FBG)

fasting insulin (FINS)

glycosylated hemoglobin (HbAlc)

HMGB 1 and serum visfatin 1 were tested. The insulin resistance index (HOMA-IR) was calculated and the electrocardiographic examination was performed before and after treatment. The anginal attacks and nitroglycerin dosage were recorded during observation period. The blood fat and score of Qi and Yin deficiency and blood stasis syndrome were tested. Result: After treatment

the efficient rate of the combination group was 96.65%

which was superior to 80.43% in control group (P<0.05). Levels of FINS

HOMA-IR and HbAlc in the combination group were less than those in control group (P<0.01). Cases of restoring normal with TG and HDL-C in the combination group were higher than those in control group (P<0.05). The number of angina pectoris attack each week and the dosage of nitroglycerin in the combination group were lower than those in control group (P<0.01). Nitroglycerin stopped reduction rate was 84.8% in the combination group

which was more than the rate of 65.2% in control group (P<0.05). Serum HMGB1 in both groups declined compared with the data before treatment. Besides

the degree of declining in the combination group was lower than that in control group (P<0.01). Level of serum retinal element 1 in both groups went up as compared with the data before treatment

while the risen degree in the combination group was higher than that in control group (P<0.01). Conclusion: On the basis of conventional western medicine treatment

adding XTD coud improve insulin resistance

enhance insulin sensitivity

regulate lipid metabolism

improve the symptoms of coronary heart disease. Its action mechanism may be related to reducing proinflammatory meson HMGB1 and enhancing the level of serum retinal element 1.