Objective: To evaluate the efficacy of traditional Chinese medicine (TCM) of tonifying the kidney combined with western medicine in the treatment of senile dementia and to provide references for choosing suitable treatment plan in clinic. Method: The randomized controlled trials (RCTs) about TCM of tonifying the kidney combined with western medicine versus western medicine at home and abroad were comprehensively searched and collected. The data was extracted from each study and a meta-analysis was conducted with RevMan5.2.Result: Eleven studies were involved in the Meta-analysis

of which 8 studies reported on the effective cases were carried out by meta-analysis. The total RR was 1.39

95%CI(1.25

1.56) and the funnel plot was approximately symmetry. It was suggested that the effect of the therapy groups was better than the control groups (Z=5.77

P<0.01). Seven studies reported minimum mental state exconination(MMSE) scores were carried out by meta-analysis. The total MD was 2.13

95%CI(0.84

3.41) and the funnel plot was approximately symmetry. It was suggested that the therapy groups was better than the control groups on senile dementia in improving cognitive function (Z=3.24

P<0.01). Conclusion: TCM of tonifying the kidney combined with western medicine in treating senile dementia is effective. However

it still needs further study.