XU Bing-wan, HUANG Jia-wei. Optimization of -Cyclodextrin Inclusion Process of Volatile Oil from Moslae Herba by Multi-objective Genetic Algorithm[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(4): 15-18.
DOI:
XU Bing-wan, HUANG Jia-wei. Optimization of -Cyclodextrin Inclusion Process of Volatile Oil from Moslae Herba by Multi-objective Genetic Algorithm[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(4): 15-18. DOI: 10.13422/j.cnki.syfjx.2015040015.
Optimization of -Cyclodextrin Inclusion Process of Volatile Oil from Moslae Herba by Multi-objective Genetic Algorithm
Objective: To investigate feasibility of multi-objective genetic algorithm(MOGA) for optimizing β-cyclodextrin(β-CD) inclusion process of volatile oil from Moslae Herba
thus allowing for subsequent assessment. Method: Taking ratio of β-CD to valatile oil
inclusion temperature and stirring time as factors
with oil content and yield of inclusion compound of volatile oil from Moslae Herba as indexes
β-CD inclusion process of volatile oil was optimized by SGAIAB beta 5008
a plug-in toolbox of Matlab 2009a software
optimization of genetic algorithm entailed statistical analysis by SPSS 19.0 software
whose result was compared with orthogonal test. Result: Optimum inclusion process was:ratio of β-CD to volatile oil 8: 1
inclusion temperature at 59 ℃
inclusion time of 2.8 hours.Following application of MOGA
yield and oil content of inclusion complex were 84.18% and 79.97%
respectively. Conclusion: For multiple targets to be optimized simultaneously
MOGA provides a more reasonable approach for optimizing condition of β-CD inclusion process of volatile oil from Moslae Herba compared with Pareto non-inferior solution and can provide some theoretical basis for preparation of Chinese patent medicines containing Moslae Herba.