Objective: In order to make the berberine and splicing of certain chemical composition

needing to form an intermediate largely

through design and experiment

synthesis of 9-O aminoberberine derivatives. Method: With berberine as starting material

through to methyl

bromo

amination reaction

obtain berberrabine

9-O-(4'-bromobutane) berberine

the final synthesis of 9-O-(4'-butyl amine) berberine

and to determine its relative molecular mass and molecular structure by means of spectroscopic. Result: Through a series of chemicalreactions in organic synthesis are berberrabine and 9-O-(4'-bromo-butane) of berberine

through the optimization of the literature method to prepare 9-O-(4'-butyl amine) berberine derivative

and through the ESI-MS

NMR spectroscopy to determine the structure. Conclusion: By optimizing the method greatly improves the product of 9-O-(4'-butyl amine) berberine yield

and the synthesis process is simple and easy to operate.From the object structure

the terminal amino

can react with various chemical groups

and then introduce the new group

to synthesize more derivatives.