Objective: To detect pharmacokinetics process of quercetin-poly(lactic-co-glycolic acid)(PLGA) block copolymer nanoparticles lyophilized powder in rats

then provide a reference for development and utilization of quercetin preparation. Method: HPLC was employed to determine plasma concentration of quercetin in rats with mobile phase of methanol-4.3% acetic acid solution(75: 25) and detection wavelength at 254 nm

bioequivalence of quercetin-PLGA block copolymer nanoparticles lyophilized powder and intravenons emulsion was compared. Result: Main pharmacokinetic parameters of quercetin-PLGA block copolymer nanoparticles in mice displayed that Cmax 16.129 mg · L-1

t1/2 7.384 h

CL 0.362 L · h-1 · kg-1

AUC0-t 99.461 mg · L-1 · h-1.At the same dose

main pharmacokinetic parameters of the quercetin emulsions group and the quercetin nanoparticles group were highly significant differences.Elimination half-life of the quercetin nanoparticles group was 1.52 times of the quercetin emulsions group.Compared with quercetin emulsions

relative bioavailability of quercetin nanoparticles was 172.92%. Conclusion: Quercetin-PLGA block copolymer nanoparticles significantly change pharmacokinetic behavior of quercetin

drug elimination time slows down

while bioavailability increases.It has a broad application prospects in anti-tumor

especially in treatment of tumor resection of residual disease.