ZHANG Li-hua, XU Xin-de, SHAO Bin, et al. Pharmacokinetic of Microencapsulated Canthaxanthin in Rabbit[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(4): 98-101.
DOI:
ZHANG Li-hua, XU Xin-de, SHAO Bin, et al. Pharmacokinetic of Microencapsulated Canthaxanthin in Rabbit[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(4): 98-101. DOI: 10.13422/j.cnki.syfjx.2015040098.
Pharmacokinetic of Microencapsulated Canthaxanthin in Rabbit
Vz/F=(1 569.453±258.575) L · kg-1。 结论: 家兔灌胃给予斑蝥黄微胶囊后
斑蝥黄在体内消化吸收缓慢、体内分布广泛
说明斑蝥黄微胶囊具有稳定和缓释的特点。
Abstract
Objective: To study the pharmacokinetic features of microencapsulated canthaxanthin in healthy rabbit. Method: Blood samples were collected from the hind limb vein at different time point after administration of a single dose of microencapsulated canthaxanthin. Plasma canthaxanthin concentration was determined by LC-MS. The main pharmacokinetic parameters were calculated by DAS2.1 program. Result: The concentration-time data of canthaxanthin fitted to a two-compartment model. The main pharmacokinetic parameters were as follows:Tmax=300 min
Cmax=(75.761±0.739) μg · L-1
t1/2z=(527.408±208.401) min
AUC(0-t)=(23 057.221±1 582.299) μg · L-1 · min-1
Vz/F=(1 569.453±258.575) L · kg-1. Conclusion: The microencapsulated canthaxanthin is slowly absorbed
possesses large volume of distribution
and shows stable and sustained-release characteristics in body.
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