Objective: To observe the effect of Shenqi compound recipe on the glucose and lipid metabolism and the protective effect on skeletal muscle of mice with type 2 diabetic macroangiopathy. Method: Selected 60 KKAy mice were randomly divided into the KKAy group

the model group

the Shenqi compound recipe group (14.4 mg · g-1 · d-1) and the rosiglitazone group (1.33 μg · g-1 · d-1) (n=15)

another 15 C57BL/6J mice were assigned to the normal group. Spontaneous type 2 diabetic KKAy mice were induced by feeding water containing nitric oxide synthase inhibitor L-arginine methyl ester (L-NAME) and a high fat diet for 8 weeks except for mice in the KKAy group and the normal group. The general conditions

as well as blood sugar levels of animals were monitored. The levels of total cholesterol (TC)

triglyceride (TG)

high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterin (LDL-C) were detected. The morphological changes of the abdominal aorta and skeletal muscle were analyzed. Result: Compared with the normal group

the food intake

the water intake

the urine volume

the weight and the blood sugar increased in the KKAy group

the scratches and wounds were found in the body surface of the model and KKAy groups

the levels of TC

TG

HDL-C and LDL-C raised in the model (P<0.01) and the KKAy (P<0.05) groups. Compared with the model group

the blood sugar

the levels of TC

TG

HDL-C and LDL-C declined significantly in the Shenqi compound recipe group (P<0.05

P<0.01). Moreover

Shenqi compound recipe could improve abdominal aortic intimal edema

improve the skeletal muscle atrophy

edema

fracture

inflammatory state situation when compared with the model group. Conclusion: Shenqi compound recipe could improve the glucose and lipid metabolism

the vascular lesion of mice with type 2 diabetic macroangiopathy

and protect skeletal muscle.