Preliminary Screening of Anti-inflammatory Active Fractions from Fruits of  of Uighur Medicine

JIANG Si-si; MA Wen-na; LU Wen-jie; MA Gui-zhi

doi:10.13422/j.cnki.syfjx.2015040144

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Preliminary Screening of Anti-inflammatory Active Fractions from Fruits of of Uighur Medicine

更新时间：2024-01-04

- Preliminary Screening of Anti-inflammatory Active Fractions from Fruits of of Uighur Medicine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 4, Pages: 144-148(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015040144
  CLC： R29
- Published：2015
- 稿件说明：
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JIANG Si-si, MA Wen-na, LU Wen-jie, et al. Preliminary Screening of Anti-inflammatory Active Fractions from Fruits of of Uighur Medicine[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(4): 144-148.
DOI：

JIANG Si-si, MA Wen-na, LU Wen-jie, et al. Preliminary Screening of Anti-inflammatory Active Fractions from Fruits of of Uighur Medicine[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(4): 144-148. DOI： 10.13422/j.cnki.syfjx.2015040144.

摘要

目的: 初步确定维吾尔族药刺山柑果实抗炎活性最强的部分。方法: 分别采用蒸馏水、80%乙醇和石油醚对刺山柑果实进行提取

制备不同极性提取物

并以此分组。SPF级昆明种小鼠240只

分别采用小鼠右后肢足趾中部ih 1%的角叉菜胶至小鼠足肿胀实验、二甲苯致小鼠耳廓肿胀实验

两组实验均分为维吾尔族药刺山柑果实水提部位高、中、低剂量组(7.903

3.952

1.976 g ·kg-1)

维吾尔族药刺山柑果实石油醚部位高、中、低剂量组(2.935

1.468

0.734 g ·kg-1)

80%乙醇高、中、低剂量组(5.644

2.822

1.411 g ·kg-1)及雷公藤多苷组(8.5 mg ·kg-1)

羧甲基纤维素纳(CMC-Na)组和食用油组

每组10只;每日给予相应药物1次

连续14 d

第14天在给药60 min后

两组实验分别给予造模剂。小鼠足肿胀实验注射角叉菜胶后30 min

6 h用足爪肿胀测量仪测定小鼠致炎右后足趾容积

同时将致炎足自踝关节以上1 cm剪下

测定前列腺素E2(PGE2)含量;小鼠耳廓肿胀实验小鼠右耳涂抹二甲苯20 μL致炎

1 h后取左耳片和右耳片称重

计算耳肿胀度。结果: 与食用油组和CMC-Na组比较

雷公藤多苷组和各提取部位组均能降低不同时间点的足肿胀

并能降低PGE2含量

尤其是水提部位高、中、低剂量组具有明显统计学差异(P<0.05);与食用油组和CMC-Na组比较

雷公藤多苷组和各提取部位组均能降低小鼠耳肿胀度

水提部位高、中、低剂量组具有明显统计学差异(P<0.05)。结论: 动物实验结果提示刺山柑果实水提取物具有良好的抗急性炎症作用

可初步确定为维吾尔族药刺山柑果实抗炎活性部分。

Abstract

Objective: To identify the anti-inflammatory active fraction from fruits of Capparis spinosa preliminarily of Uighur medicine. Method: Fruits of Capparis spinosa were extracted by distilled water

80% ethanol and petroleum ether to obtain the different polar fractions groups. Every polar extractions was divided into high

middle

low groups

respectively. The tripterygium glycosides tablet was selected as a positive control drug. The anti-inflammatory active fraction was screened through auricle edema induced by xylene and paw edema induced by carrageen in mice. After 14 days of treatment

the degree of auricle edema and paw edema were measured

the prostaglandin E2 (PGE2) of ankle was detected. Result: The results suggested the foot swelling degree was inhibited

the PGE2 content decreased in the tripterygium glycosides tablet and all extracts groups in xylene-induced auricle edema mice (P <0.05). The paw edema degree was inhibited in the tripterygium glycosides tablet and all extracts groups in carrageen-induced paw edema mice (P <0.05). The distilled water extracts at all doses from Capers fruits had the best results on acute inflammatory reactions than the other groups(P <0.05). Conclusion: Distilled water extracts from Capers fruits have potential anti-inflammation effect. The distilled water extracts may be the anti-inflammatory active fraction from fruits of C. spinosa.

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