Effect of Tongluo Huazhuo Decoction on Carotid Intima-media Thickness in Patients with Diabetes Disease

WANG Xiang-rong; MENG Ran

doi:10.13422/j.cnki.syfjx.2015040193

您当前的位置：

首页 >

文章列表页 >

Effect of Tongluo Huazhuo Decoction on Carotid Intima-media Thickness in Patients with Diabetes Disease

更新时间：2024-01-04

- Effect of Tongluo Huazhuo Decoction on Carotid Intima-media Thickness in Patients with Diabetes Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 4, Pages: 193-196(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015040193
  CLC： R285.6
- Published：2015
- 稿件说明：
移动端阅览
WANG Xiang-rong, MENG Ran. Effect of Tongluo Huazhuo Decoction on Carotid Intima-media Thickness in Patients with Diabetes Disease[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(4): 193-196.
DOI：

WANG Xiang-rong, MENG Ran. Effect of Tongluo Huazhuo Decoction on Carotid Intima-media Thickness in Patients with Diabetes Disease[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(4): 193-196. DOI： 10.13422/j.cnki.syfjx.2015040193.

摘要

目的: 探讨通络化浊汤对糖尿病颈动脉内膜中层厚度(IMT)和对血清炎症因子和内皮功能的影响。方法: 将96例伴有颈动脉IMT增厚的2型糖尿病患者随机按数字表法分为对照组和观察组各48例。对照组采用阿托伐他汀钙片20 mg/次

1次/d

晚餐后服用;观察组在对照组治疗的基础上加用通络化浊汤

1剂/d。两组疗程均为4个月。进行治疗前后颈动脉IMT和斑块面积测量

检测治疗前后甘油三酯(TG)

总胆固醇(TC)

高密度脂蛋白胆固醇(HDL-C)

低密度脂蛋白胆固醇(LDL-C)水平;检测治疗前后空腹血糖(FBG)

空腹胰岛素(FINS)

糖化血红蛋白(HbAlc)

并计算胰岛素抵抗指数(HOMA-IR);检测治疗前后肿瘤坏死因子α(TNF-α)

高敏C反应蛋白(hs-CRP)

脂联素(APN)

同型半胱氨酸(Hcy)和血管性血友病因子(vWF)水平。结果: 治疗后两组颈动脉IMT厚度和斑块面积均比治疗前缩小(P<0.01)

观察组颈动脉IMT厚度和斑块面积P<0.01);治疗后观察组TC水平低于对照组

HDL-C水平高于对照组(P<0.05);治疗后两组FBG

HbA1c

FINS和HOMA-IR均比治疗前下降(P<0.01)

治疗后组间差异无统计学意义;治疗后观察组TNF-α

hs-CRP

Hcy和vWF水平低于对照组(P<0.01)

APN水平高于对照组(P<0.01)。结论: 通络化浊汤联合阿托伐他汀钙片能减轻颈动脉IMT厚度和缩小斑块面积

其作用机制可能与调节T2 DM患者脂代谢

减轻炎症反应

改善内皮功能有关。

Abstract

Objective: To discuss the influence of Tongluo Huazhuo decoction on carotid intima-media thickness (IMT)

serum inflammatory factors and endothelial function in treating diabetes disease. Method: Ninety-six patients with carotid artery IMT of type 2 diabetes were randomly divided into the control group (48 cases) and the observation group (48 cases) by a random number table. Patients in the control group received 20 mg atorvastatin calcium tablets at night once daily. Based on the treatment of the control group

patients in the observation group added 1 dose Tongluo Huazhuo decoction once daily. All patients in two groups received 4 months of treatment. Before and after the treatment

carotid IMT and artery plaque area were detected

and levels of triglyceride (TG)

total cholesterol (TC)

high density lipoprotein-C (HDL-C) and low density lipoprotein-C (LDL-C) were also detected. Besides

fasting blood glucose (FBG)

fasting insulin (FINS) and glycosylated hemoglobin (HbAlc) were detected and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated

while levels of tumour necrosises factor-α (TNF-α)

high-sensitivity C-reactive protein (hs-CRP)

adiponectin (APN)

homocysteine (HCY) and von Willebrand factor (vWF) were detected. Result: The carotid IMT and artery plaques area in two groups declined compared with the data before treatment (P<0.01). The carotid IMT and artery plaques area in the observation group were less than those in the control group (P<0.01). TC level in the observation group was lower

while the HDL-C level was higher than that in the control group (P<0.05). FBG

HbA1c

FINS and HOMA-IR of both groups decreased after treatment (P<0.01). There was no statistically significant difference between two groups. TNF-α

hs-CRP

Hcy and vWF levels in the observation group were lower than those in the control group (P<0.01). Besides

the APN level was lower than that in the control group (P<0.01). Conclusion: Tongluo Huazhuo decoction could reduce the carotid IMT and artery plaques area. Its mechanism may be related to adjusting lipid metabolism

reducing inflammation and improving endothelial function in type 2 diabetes patients.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Protective Effect of Modified Qiju Dihuang Pills on Renal Function of Patients with Early Renal Impairment

Effect of Co-treatment Method of Stagnation of Phlegm and Blood Stasis （Danlou Tablet） on Vascular Endothelial Function in Patients with Atherosclerosis

Effect of Gynostemma pentaphyllum Alcohol Extract on Glucose and Lipid Metabolism Disorders in db/db Mice Based on Transcriptomics and Gut Microbiota

Yijingtang Reduces Ovarian Inflammatory Responses in Rat Model of Diminished Ovarian Reserve via TLR4/MyD88/NF-κB Signaling Pathway

Mechanism of Shengmai Injection Against Cerebral Ischemia Based on Proteomics

Related Author

Xi-qin CAO

Kai LIU

Zuo-han LEI

Ya-jun BING

WU Qian

HOU Xinzheng

LYU Qianyu

YE Xuejiao

Related Institution

Gansu Provincial Hospital of Traditional Chinese Medicine (TCM)

Traditional Chinese and Western Medicine College, Gansu University of TCM

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

Dongfang Hospital， Beijing University of Chinese Medicine

Beijing University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰