Objective: To discuss the clinical effect of Xiaoyu Kuanxiong decoction combined with closed drainage of the pleural cavity in treating traumatic hemothorax and to investigate its influence on patients' blood coagulation and hemorheology. Method: Seventy-six patients were randomly divided into the control group (38 cases) and the observation group (38 cases) by a random number table. Patients in the control group received combined treatment

mainly closed drainage of pleural cavity therapy. Based on the treatment of the control group

patients in the observation group added 1 dose Xiaoyu Kuanxiong decoction once daily. All patients in two groups received 12 weeks of treatment. The volume and duration of drainage

and the length of hospital stays were recorded. The occurrence rates of coagulated hemothorax and fibrothorax were observed during the follow-up. Before and after one week of treatment

prothrombin time (PT)

activated partial thromboplastin time (APTT)

fibrinogen (FIB) and D-dimer (D-D) in plasma were detected

and the hemorheology indexes

levels of thromboxane B2(TXB2) and 6-ketone-prostaglandin F1α(6-Keto-PGF1α) were also detected. Result: The clinical curative effect of the observation group was superior to that of control group. There was statistically significant difference between two groups (P<0.05). The volume and duration of drainage

and the length of hospital stays in the observation group were less than those of the control group (P<0.05). The incidence of coagulated hemothorax or fibrothorax in the control group was 18.42%

which was higher than 2.63% in the observation group

but there was no statistically significant difference between two groups. After a week of treatment

the levels of D-D and FIB in the observation group were lower than those in the control group (P<0.01). Improvement of blood rheology indexes (whole blood viscosity

plasma viscosity

erythrocyte sedimentation rate

platelet aggregation rate

whole blood reduced viscosity) in the observation group were superior to those in the control group (P<0.01). TXB2level of the observation group was less than that of control group (P<0.01)

while the 6-Keto-PGF1α level in the observation group was higher than that in the control group (P<0.01). Conclusion: Xiaoyu Kuanxiong decoction could reduce drainage of traumatic hemothorax patients

shorten the distance of disease

improve blood circulation and promote the blood running smoothly. Besides

it could reduce the incidence of coagulated hemothorax or fibrothorax.