Puerarin

a kind of flavonoid compound

was extracted from Puerariae Radix. It showed neuroprotective effects on a variety of brain damage. Studies have found that puerarin had many activities such as reducing the toxic of excitatory amino acids

inhibiting oxidative stress

antagonising Ca2+ overload

reducing inflammation

inhibiting apoptosis

relieving cerebral edema and so on. Multiple studies have demonstrated that puerarin has significant efficacy in the treatment of Parkinson

cerebral infarction

cerebral ischemia syndrome and other diseases of the nervous system. In recent years

the researches relevant to puerarin continue to emerge. This paper provides a summarization of the nearest decade research progress of the puerarin neuroprotective mechanisms

in order to provide some references for studying the neuroprotective effect of puerarin. Through consulting a number of literature materials

the authors found that the study on neural protection mechanism of puerarin in some parts is still not deep enough

especially the genetic level. Neuroprotective mechanisms of puerarin are very complex

and therefore need to strengthen multidisciplinary cooperation to study of its mechanisms in-depth

so as to find more ways of puerarin neuroprotective mechanisms. With the development of modern research methods and techniques of molecular biology

exploring puerarin neuroprotective mechanisms at gene level will be a new orientation. That will bring a new breakthrough for the clinical application of puerarin and explore a new way for prevention and treatment of neurological diseases.