Objective: To illuminate effects of viscosity on release of sustained-release preparations after compatibility of homemade slow-release improved accessory I and others. Method: With Chuanping extract as a model drug and dextrin as a filler

different sustained-release tablets(prescription A

B

C) with different dosage of modified accessory I(40%

45% and 50%) were prepared;sustained-release tablets(prescription D

E

F

G) with the best proportion of modified accessory I and other accessories[lactose

dextin-sugar(1: 1)

starch-sugar(1: 1)

microcrystalline cellulose] were prepared.HPLC was adopted to measure release rates of ephedrine

pseudoephedrine and scopolamine in Chuanping sustained-release tablets

balanced release of different component were determined by similarity factor method. Result: Torque of accessory I was less than 10%

viscosity of improved accessory I was 218.3×10-3 Pa·s.Viscosities of prescriptions A

B

C were 105×10-3

265×10-3

540×10-3 Pa·s;release finished at 6

8

10

respectively.Finished-release time of prescription C met demand

release of ephedrine

pseudoephedrine and scopolamine at 10 h were 97.21%

96.79%

94.21%

releasing factor(f2) values were 75.08

71.42

61.88

balanced release rates were obtained well.Viscosities of prescription D

E

F

G were 400×10-3

435×10-3

475×10-3

808.3×10-3 Pa·s

finished-release times were 8

>10

10

2 h

respectively.Prescription F met requirement

release degrees of ephedrine

pseudoephedrine and scopolamine at 10 h were 98.40%

97.92%

97.99%

f2 values were 74.78

74.65

74.70

balanced release rates were obtained well. Conclusion: Improved accessory I can meet demand of balanced release well.Compatibility of different accessories can affect balanced release of Chuanping sustained-release tablets.When different dosages of improved accessory I combine with dextrin

viscosity and release are positively correlated;when improved accessory I is compatible with different filler

viscosity and release are negatively correlated.