Objective: To optimzie preparation process of pomegranate peel polyphenols liposomes by using supercritical CO2 fluid precipitation technology. Method: With entrapment efficiency as index

main factors were screened by Plackett-Burman test

preparation process of pomegranate peel polyphenols liposomes was optimized by steepest ascent test and Box-Behnken test. Result: Ratio of raw materials and membrane material

reaction temperature and pressure were significant factors

optimal preparation conditions was as following:ratio of raw materials and membrane material of 1: 21.15

reaction temperature at 48.3 ℃

reaction pressure of 23.88 MPa.The measured value and the predicted value of entrapment efficiency were 80.295% and 81.379%

effective size was 168.5 nm

Zeta potential was -73.8 mV. Conclusion: This test model meets requirements.In vitro release of pomegranate peel polyphenols liposomes is slow

its sustained release effect is obvious.