ZHANG Jin-hua, XIONG Yong-ai. Effect of Paeonol on Rats' Ischemic Arrhythmia and miRNA-1 Expression[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(5): 129-132.
DOI:
ZHANG Jin-hua, XIONG Yong-ai. Effect of Paeonol on Rats' Ischemic Arrhythmia and miRNA-1 Expression[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(5): 129-132. DOI: 10.13422/j.cnki.syfjx.2015050129.
Effect of Paeonol on Rats' Ischemic Arrhythmia and miRNA-1 Expression
Objective: To investigate the effect of paeonol on ischemic arrhythmia and the expression of miRNA-1 of rats. Method: SPF SD rats were randomly divided into the normal group
the model group
the positive group (propranolol hydrochloride injection 2 mL·kg-1) and the paeonol group (6
3
1 mg·kg-1). The ischemic arrhythmia models were induced by injecting 5 μg·kg-1dose of aconitine intravenously. ECG changes of each group were recorded
premature beat (VPB) frequency and time for the first time
and ventricular tachycardia (VT) and ventricular fibrillation (VF) frequency and duration were recorded. Hearts were taken out on the end of the experiment
myocardial infarct sizes were measured
and the expression of miRNA-1 in myocardial cells was measured by RT-qPCR method. Result: Compared with the normal group
the ischemic arrhythmia was occurred
the frequencies of VPB
VT and VF increased
the VPB time for the first time shortened
the VT and VF durations increased
myocardial infarct sizes and miRNA-1 expression increased in the model group (P<0.05
P<0.01).The above indicators had good improvement in the paeonol group(P<0.05
P<0.01). Conclusion: Paeonol has an obvious effect in treating ischemic arrhythmias.
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