Efficiency and Influence of Inflammatory Cytokines by Yaobitong Capsule in Rat Lumbar Disc Herniation Model

TANG Zhao-hui; CAO Liang; DING Gang; WANG Zhen-zhong; XIAO Wei

doi:10.13422/j.cnki.syfjx.2015050155

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Efficiency and Influence of Inflammatory Cytokines by Yaobitong Capsule in Rat Lumbar Disc Herniation Model

更新时间：2024-01-04

- Efficiency and Influence of Inflammatory Cytokines by Yaobitong Capsule in Rat Lumbar Disc Herniation Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 5, Pages: 155-158(2015)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2015050155
  CLC： R285.5
- Published：2015
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TANG Zhao-hui, CAO Liang, DING Gang, et al. Efficiency and Influence of Inflammatory Cytokines by Yaobitong Capsule in Rat Lumbar Disc Herniation Model[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(5): 155-158.
DOI：

TANG Zhao-hui, CAO Liang, DING Gang, et al. Efficiency and Influence of Inflammatory Cytokines by Yaobitong Capsule in Rat Lumbar Disc Herniation Model[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(5): 155-158. DOI： 10.13422/j.cnki.syfjx.2015050155.

摘要

目的: 建立大鼠腰椎间盘突出模型

观察腰痹通胶囊(YBT)对该模型的药效及血清炎性因子的影响。方法: 利用硅胶片模拟腰椎间盘突出

压迫大鼠L5神经根

建立大鼠腰椎间盘突出动物模型

并随机分为模型组、阳性药组(腰痛宁胶囊0.16 g·kg-1)和YBT治疗3个剂量(0.17

0.34

0.68 g·kg-1)组

另设正常组

给药30 d后

检测大鼠左后肢压痛痛阈、血清肿瘤坏死因子-α(TNF-α)

白介素-1β(IL-1β)

白介素-6(IL-6)及神经根病理变化。结果: 成功复制大鼠腰椎间盘突出模型。与正常对照组比较

模型组大鼠左后肢压痛痛阈明显降低(P<0.05)

血清TNF-α

IL-1β

IL-6含量明显升高(P<0.01)、神经根有明显病变;YBT 0.34

0.68 g·kg-1剂量组可以显著提高模型大鼠左后肢压痛痛阈、降低血清3种炎性因子含量(P<0.05

P<0.01)、改善神经根病变。结论: 腰痹通胶囊可以改善腰椎间盘突出动物模型的症状及神经根病变

其机制可能与抑制炎性因子释放有关。

Abstract

Objective: To study the effect of Yaobitong capsule(YBT)on inflammatory cytokines and pain in the rat lumbar disc herniation model (RLDHM). Method: The model of lumbar disc herniation(LDH) was established by compressing silica gel pieces on the L5 nerve root of rat. All the rats were randomized into model group

positive group(Yaotongning capsules

0.16 g·kg-1)and YBT treatment groups(0.17

0.34

0.68 g·kg-1). After administration for 30 d

the mechanical pain thresholds of left hind limb

serum tumor necrosis factor-α(TNF-α)

interleukin-1β(IL-1β)

interleukin-6(IL-6)levels and pathological change in the nerve root of rats were detected respectively. Result: The model of LDH in rats was successfully established. Compared with normal control group

the mechanical pain thresholds of the model rats were decreased significantly(P<0.05)

the serum TNF-α

IL-1β

IL-6 levels were increased significantly(P<0.01)

and the obvious lesion was observed in nerve root. In the 0.34

0.68 g·kg-1 dose of YBT groups

the mechanical pain thresholds were increased significantly

the serum TNF-α

IL-1β

IL-6 levels reduced significantly(P<0.05

P<0.01)

and the pathological change was improved obviously in the nerve root. Conclusion: YBT could improve the symptoms and nerve root lesions in rats with LDH

which may be related with inhibition of inflammatory cytokines.

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Related Institution

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